Broad-Spectrum Abnormal Localized Photosensitivity Syndrome
This case report describes a man in his 50s with broad-spectrum abnormal localized photosensitivity syndrome.
Medical Knowledge
Epiretinal Hyperproliferative Complex
This case report discusses a diagnosis of epiretinal hyperproliferative complex in a male patient aged 75 years with a history of multiple myeloma who reported blurred vision in his left eye persisting after cataract surgery.
Hoarseness With Supraglottic Ulcer in an Immunocompetent Adult
A 61-year-old man presented to the otolaryngology clinic with a 2-month history of progressive hoarseness, dysphagia, odynophagia, and persistent globus sensation. What is your diagnosis?
Head and Neck Cancer – A Review
Importance Head and neck cancer, which arises in the lining or mucosa of the upper aerodigestive tract, specifically the oral cavity, oropharynx, larynx, hypopharynx, and paranasal sinuses, is the seventh most common cancer worldwide. In 2024, approximately 71 110 individuals in the…
Patient-Centered Prioritization of Health Care Processes for Multimorbidity
Importance Primary care provides a broad service range, including preventive screenings and chronic disease care. Busy clinicians frequently select which health care processes to address per visit based on time or perceived disease impact, especially for patients with multimorbidity. Little evidence…
Myocardial Dysfunction in Primary Mitral Regurgitation – A Review
Importance Primary mitral regurgitation (MR) is a prevalent valvular lesion. Current American College of Cardiology/American Heart Association guidelines include class I recommendations for intervention for severe primary MR at the onset of symptoms, significant left ventricular (LV) enlargement (end-systolic dimension ≥40…
Reinforcement Learning for Finding Optimal Dynamic Treatment Regimes Using Observational Data
This Guide to Statistics and Methods provides an overview of using observational data and reinforcement learning strategies to develop dynamic treatment regimes for patients who are critically ill.
A Nonhealing Ulceration of the Hand
A woman in her 30s presented with a chronic, painful, nonhealing ulcer on her fifth finger that developed after trauma 1 year earlier. What is your diagnosis?
Enhancing Clinical Cancer Research Through Sharing of Data and Biospecimens
Importance Molecular analyses of biospecimens collected from study participants are essential for identifying biomarkers that can tailor treatments to specific subsets of patients who are most likely to benefit. Sharing of data and biospecimens from clinical trials enables personalized, patient-centric use…
Progression of Presumed Pentosan Polysulfate Sodium Maculopathy After Drug Cessation
This case report discusses presumed progression of maculopathy secondary to pentosan polysulfate sodium prescribed for daily use over a period of 4 years in a patient with a history of interstitial cystitis.
