Medical Knowledge

Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer – The ORCHESTRA Randomized Clinical Trial

Importance  Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking. Objective  To investigate whether tumor debulking added to palliative…

Lighting the Way to Patient-Centered Alzheimer’s Care: Employing Amyloid-Targeting Therapies Safely and Effectively Through Careful Patient Selection and Shared Decision-Making

As the population ages, dementia is emerging as a significant public health concern. Pursuit of strategies for dementia risk reduction and disease-modifying treatments (DMTs) have become key focal points of global research and public health action plans. Despite this growing…

Extensive Oral Ulcerations After Stem Cell Transplant

A 69-year-old male patient presented with worsening new-onset oral ulcerations and pain. He had myelodysplastic syndrome and underwent an allogeneic hematopoietic stem cell transplant 18 months prior. What is your diagnosis?