Classification and Risk Assessment of Chronic Kidney Disease
This JAMA Clinical Guidelines Synopsis summarizes KDIGOís 2024 clinical practice guideline for evaluation and management of chronic kidney disease.
Medical Knowledge
Diagnosis and Management of Hemodialysis Access Complications – A Review
Importance More than 100 000 patients in the US begin hemodialysis each year. While arteriovenous fistulas (AVFs) have been the preferred dialysis access due to their durability and lower complication rates, contemporary guidelines now emphasize achieving a functional access tailored to individual…
Psilocybin Outside the Clinic – Public Health Challenges of Increasing Publicity, Accessibility, and Use
Importance Psilocybin use has surged in the US following decriminalization efforts and promising clinical trial results. Mirroring early cannabis legalization, public access and enthusiasm are outpacing regulatory oversight and scientific understanding, posing potential risks to public health. Objective To review emerging evidence…
Multiloculated Lesion of Right Mandibular Angle
A healthy 25-year-old female presented with an 8-month history of a painful right mandibular lesion. What is your diagnosis?
Acute Unilateral Uveitis With Hypopyon and an Iris Lesion
A previously healthy 31-year-old woman presents with acute unilateral anterior uveitis with hypopyon and an iris lesion and systemic symptoms, including headache, fatigue, and fever. What would you do next?
Emerging Artificial Intelligence Technologies for Risk Assessment and Management in Acute Myeloid Leukemia
Importance Acute myeloid leukemia (AML) is a severe hematologic cancer with complex genetic heterogeneity necessitating personalized treatment approaches. Artificial intelligence (AI) technologies may revolutionize risk stratification, diagnosis enhancement, and treatment planning in addressing critical gaps in AML management, particularly in low-resource…
Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia
Importance Persons with heterozygous familial hypercholesterolemia (HeFH) are at increased risk of atherosclerotic cardiovascular disease due to lifelong elevated levels of low-density lipoprotein cholesterol (LDL-C). Many patients with HeFH do not achieve guideline-recommended LDL-C goals with the currently available lipid-lowering therapies….
Coronary Computed Tomography Angiography in Prediction of First Coronary Events
Importance Risk stratification strategies in primary prevention of coronary events lack precision. Objective To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort…
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation – The DECAF Randomized Clinical Trial
Importance Conventional wisdom holds that caffeinated coffee is proarrhythmic. Coffee is the most commonly consumed caffeinated beverage in the US, and a randomized trial assessing caffeinated coffee consumption in patients with atrial fibrillation (AF) has not previously been performed. Objective To determine…
DASH-Patterned Groceries and Effects on Blood Pressure – The GoFresh Randomized Clinical Trial
Importance The Dietary Approaches to Stop Hypertension (DASH) eating plan lowered blood pressure (BP) among Black adults in a controlled environment, but to date, there are no grocery shopping strategies that replicated its health effects in a community setting. Objective The Groceries…
