Importance Emergency departments (EDs) serve patients at high risk for overdose. There is increasing interest in peer-delivered ED interventions for substance use but little rigorous research on their effectiveness. Objective To examine the effectiveness of an initiative (Relay) operated by…
Importance The ongoing consequences of settler colonialism produce adverse structural drivers, particularly nutrition insecurity, that contribute to cardiovascular health disparities among Indigenous populations. There is increased focus in Native communities to reclaim traditional precontact foods to improve health. Therefore, a…
Importance Over 1 million pulmonary nodules are discovered each year in the US, and many of these undergo molecular imaging–guided surgery to obtain a diagnosis. Locating a small nodule and determining its malignant potential is technically challenging and is prone…
Importance Excess body weight, which is associated with poor survival after breast cancer (BC) diagnosis, is a heritable trait. Objective To investigate whether genetic predisposition to excess body weight is associated with the risk of mortality among BC survivors. Design,…
Hypertension, defined as office systolic blood pressure (SBP) 130 mm Hg or greater and/or diastolic blood pressure 80 mm Hg or greater, affects 43.9% of women and 49.5% of men in the US. Approximately 19.7% of patients treated for hypertension…
Importance Hypertension significantly increases the risk of cardiovascular diseases (CVDs) and related cardiometabolic conditions, yet the role of healthy lifestyle in modifying these risks remains underexplored. Objective To investigate associations of adherence to healthy lifestyle before and after a hypertension…
Importance Colorectal cancer liver metastases (CRLM) are a common manifestation of colorectal cancer, and clinical decision-making for these patients is complex. The timing of CRLM detection, defined as synchronous, early metachronous, or late metachronous, is hypothesized to influence survival outcomes,…
Importance Methadone, a medication for opioid use disorder, is underused in the US response to the opioid overdose crisis. Under federal law, methadone can be offered in pharmacies via medication units, although a change to federal statutes or regulations could…
Importance Hydralazine is a selectively used cardiovascular medication with case reports and case series demonstrating an association between the use of hydralazine and antineutrophil cytoplasmic antibody–associated vasculitis. Objective To assess the risk of vasculitis associated with hydralazine use compared with…
Importance Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major factor underlying US health care costs. While its clinical burden is well documented, the full economic impact of AF—particularly among working-age adults with productivity losses—remains underexplored….
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