Medical Knowledge

Ultra-Widefield OCT Angiography in Coats Plus Syndrome

This case report describes a diagnosis of Coats plus syndrome in an otherwise visually asymptomatic Chinese female aged 22 years who presented for a complete ophthalmologic examination to identify any potential retinal abnormalities.

Unilateral Iris Metastasis of Small Cell Lung Cancer

This case report describes a diagnosis of iris metastasis in a 78-year-old woman with small cell lung cancer who presented with blurred vision and redness in the right eye accompanied by headache and nausea.

Targeting MASLD and MASH in the US Hispanic/Latino Population – A Review

Importance  The prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD) in the US is highest among Hispanic/Latino individuals. Their risk of developing metabolic dysfunction–associated steatohepatitis (MASH) with fibrosis, cirrhosis with progression to hepatocellular carcinoma and need for liver transplant, and death…

How to Communicate Medical Numbers

This JAMA Insights provides evidence-based recommendations for communicating numerical information to patients.

Asymptomatic Grade 6 Diastolic Murmur in an Adult

A previously healthy 55-year-old man presented to his local family medicine clinic after waking up with a buzzing sensation in his chest. What would you do next?

Annular Cutaneous Lesion of the Neck

A woman in her 30s presented with a 1-year history of painful annular eruptions on the anterior neck, which initially appeared as several erythematous papules that gradually enlarged, coalescing into annular configurations that were occasionally accompanied by pain. What is…

Emerging EGFR-Targeted Therapy in Head and Neck Cancer – A Review

Importance  Head and neck squamous cell carcinoma (HNSCC) represents a significant global health burden with limited therapeutic options for patients with recurrent or metastatic disease. Epidermal growth factor receptor (EGFR) is overexpressed in most patients with HNSCC and represents a biologically…

The Rise in Early-Onset Cancer in the US Population—More Apparent Than Real

Importance  Rising rates of early-onset cancer have generated substantial media coverage and public concern. In response, early-onset cancer has become a federal research priority, and clinical guidelines have shifted to recommend earlier screening for some cancers. Yet, it remains unclear whether…