A 34-year-old patient with a family history of stroke had right-sided headache, left upper extremity hemiparesis, and left hand numbness; magnetic resonance angiography showed bilateral narrowing of the terminal portion of the intracranial carotid arteries, more severe on the right….
Importance Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access. Objective To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia. Design, Setting,…
This JAMA Insights discusses transmission, clinical presentation, and diagnosis of measles and emphasizes the importance of vaccination to protect those at highest risk for complications from measles, including young children and pregnant individuals.
Importance Mental health challenges among physicians represent a critical public health issue with profound implications for health care delivery and workforce sustainability. Despite the proven effectiveness of mental health treatment in improving outcomes, most physicians with mental health conditions do not…
Importance Hemorrhoidal disease, pathology of the tissue lining of the anal canal, affects approximately 10 million individuals in the US. Hemorrhoidal disease may impair quality of life due to bleeding, pain, anal irritation, and tissue prolapse. Observations Hemorrhoids are classified as internal,…
Importance Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα. Objective To assess the efficacy and safety of stapokibart as an add-on treatment to intranasal corticosteroids in patients…
This JAMA Insights explores topical treatments and systemic therapies for atopic dermatitis, the most common chronic inflammatory skin condition globally.
Importance With rapidly aging populations globally, there is a lack of evidence on effective fall prevention strategies among community-dwelling older people in resource-constrained areas. Objective To assess the effectiveness of a fall prevention program integrated in primary health care systems on the…
Importance Melanoma, the fifth most common cancer in the US, has increased from 8.8 per 100 000 in 1975 to 28.42 per 100 000 in 2022. Cutaneous melanoma comprises 94% of cases, with 104 960 US cases projected for 2025. Observations Cutaneous melanoma presents as…
A patient with a bioprosthetic aortic valve implanted 6 years prior to presentation had fevers, malaise, and weight loss. Coxiella burnetii titers, erythrocyte sedimentation rate, and levels of C-reactive protein and rheumatoid factor were elevated; transesophageal echocardiography showed a thickened…
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