Importance Mifepristone, used with misoprostol, is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration…
A patient in the upper Midwest had fever, rash, dizziness, multiple erythematous annular rashes on the back and lower extremities, and third-degree AV block. The patient reported frequently hiking outdoors but no recent travel, new medications, sick contacts, or ticks…
Importance Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance. Observations Restless legs syndrome is characterized by an overwhelming urge to move the limbs,…
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Canadian Research Initiative in Substance Matters (CRISM) guideline on management of opioid use disorder (OUD).
Importance IgA nephropathy (IgAN) is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, causing glomerular inflammation and scarring. It is the most common immune-mediated glomerular disease worldwide, and affects an estimated 198 887 to 208 184 persons in…
This Guide to Statistics and Methods provides an overview of the win ratio method for analyzing composite end points in randomized clinical trials, including its benefits and limitations.
This JAMA Insights discusses the evidence related to the US Surgeon General’s Advisory on alcohol and cancer risk.
Importance The safety and efficacy of intravenous thrombolytics beyond 4.5 hours after ischemic stroke onset remain inadequately studied. Objective To evaluate the safety and efficacy of intravenous alteplase administered 4.5 to 24 hours after stroke onset in patients with salvageable brain tissue,…
Importance The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exponentially with age. Geroscience is a relatively new discipline that aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases,…
Importance Prostatitis is defined as infection, inflammation, or pain of the prostate gland and affects approximately 9.3% of men in their lifetime. Observations Acute bacterial prostatitis consists of a urinary tract infection (UTI) that includes infection of the prostate, typically associated with…
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