A patient receiving adalimumab for rheumatoid arthritis had ulcerated plaques on the anterior and lateral aspects of the neck, upper chest, and nape and erythroderma on the dorsum of the hands, corresponding to areas of sun exposure, as well as…
Importance Globally, 968 350 new cases and 659 853 deaths from gastric cancer were reported in 2022. In the US, 30 300 new cases and 10 780 deaths were estimated in 2025. Observations Gastric cancer is more common in men, and the median age at diagnosis…
This JAMA Insights discusses postñintensive care unit syndrome, including how it is assessed and diagnosed as well as suggestions for treatment and prevention.
This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.
This JAMA Insights focuses on stillbirth, including causes, risk factors, and prenatal preventive care.
Importance Mifepristone, used with misoprostol, is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration…
A patient in the upper Midwest had fever, rash, dizziness, multiple erythematous annular rashes on the back and lower extremities, and third-degree AV block. The patient reported frequently hiking outdoors but no recent travel, new medications, sick contacts, or ticks…
Importance Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance. Observations Restless legs syndrome is characterized by an overwhelming urge to move the limbs,…
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Canadian Research Initiative in Substance Matters (CRISM) guideline on management of opioid use disorder (OUD).
Importance IgA nephropathy (IgAN) is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, causing glomerular inflammation and scarring. It is the most common immune-mediated glomerular disease worldwide, and affects an estimated 198 887 to 208 184 persons in…
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