JAMA

A 9-Year-Old Child With a Large Thoracic Mass

A healthy 9-year-old had 10 days of nonproductive cough without fever, wheeze, chest pain, or abdominal pain but with diminished breath sounds in the right lower lung field. Results of laboratory testing were unremarkable; computed tomography revealed a fat-density mass…

Prevention of Anal Cancer in High-Risk Individuals

This JAMA Insights examines the treatment and rising prevalence of anal cancer in the US in high-risk groups, including people with HIV and immunosuppression associated with solid organ transplant.

Peptic Ulcer Disease – A Review

Importance  In the US, peptic ulcer disease affects 1% of the population and approximately 54 000 patients are admitted to the hospital annually for bleeding peptic ulcers. Observations  Approximately 10% of patients presenting with upper abdominal pain in a primary care setting have…

Ovarian Aging and Fertility

This JAMA Insights discusses ovarian aging and provides strategies to address infertility due to ovarian aging.

Differences in Drug Shortages in the US and Canada

Importance  Drug shortages are a persistent public health issue that increased during the COVID-19 pandemic. Both the US and Canada follow similar regulatory standards and require reporting of drug-related supply chain issues that may result in shortages. However, it is unknown…

CAR T Cells and T-Cell Therapies for Cancer – A Translational Science Review

Importance  Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall…

A Young Woman With Headaches and Peripheral Vision Loss

A 30-year-old nulliparous woman with obesity and history of migraines and depression had 1 month of daily headaches, transient bilateral visual blurring, persistent vision loss in the temporal region of one eye, pulsatile tinnitus, and mild bilateral papilledema. What is…

Working With Medical Interpreters

This JAMA Insights discusses the important role that interpreters play in facilitating communication between patients with limited English-language proficiency and their health care team and provides steps that can be taken to improve communication with remote interpreters for patients.