Chikungunya
This JAMA Insights discusses the transmission, diagnosis, management, and prevention of chikungunya.
JAMA
Amyotrophic Lateral Sclerosis – A Review
Importance Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord. It affects approximately 25 000 individuals in the…
Promises, Pitfalls, and Paths Forward for the Pediatric Research Equity Act
Importance Since its enactment in 2003, the Pediatric Research Equity Act (PREA) has significantly increased the number of pediatric drug studies performed and expanded pediatric drug labeling. Despite these advancements, many drugs used in children still lack pediatric-specific US Food…
Treatment of Anterior Cruciate Ligament Rupture
This JAMA Insights examines the efficacy of different management strategies for anterior cruciate ligament rupture, including surgical reconstruction and structured rehabilitation.
Hepatitis B – A Review
Importance Hepatitis B virus (HBV) infection affects an estimated 254 million people worldwide and causes approximately 1.1 million deaths annually. In 2022, there were approximately 1.2 million new HBV infections worldwide and 14 000 in the US. Observations HBV is a…
Pigmentary Changes That Developed During Pregnancy
A Black woman of Hispanic ethnicity with a history of hypertension, obesity, and headaches had symmetrically distributed, well-demarcated hyperpigmented lines that had developed during pregnancy and that extended from her buttocks to the lower extremities; physical examination was otherwise unremarkable….
The Veterans Affairs’ Whole Health Approach for Chronic Pain Management – The wHOPE Randomized Clinical Trial
Importance The US Department of Veterans Affairs (VA) Whole Health approach was congressionally mandated in 2016 for patients with chronic pain receiving care in VA hospitals, but no randomized clinical trials have tested its benefits. Objective To evaluate the effectiveness…
Cardiac Resynchronization Therapy – A Review
Importance Heart failure (HF) affects more than 64 million individuals worldwide, and acute HF is associated with 1-year mortality rates of 23.6% in North America and Europe. Cardiac dyssynchrony from conduction system disease may cause HF progression, particularly in patients…
Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo
This JAMA Insights discusses the epidemiology, clinical presentation, and diagnostic evaluation of benign paroxysmal positional vertigo.
Prepregnancy Care and Counseling – A Review
Importance Prepregnancy care and counseling optimize maternal health before conception to improve outcomes for mothers and infants. In the US, 66.4% of reproductive-aged women have at least 1 modifiable risk factor for adverse pregnancy outcomes. Observations For all individuals desiring…
