Management of Acute Coronary Syndrome
This JAMA Clinical Guidelines Synopsis summarizes the 2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline for the management of patients with acute coronary syndrome.
JAMA
Caring for Adult Patients With Sepsis
This JAMA Clinical Guidelines Synopsis summarizes the newly released Surviving Sepsis Campaign guidelines from ESICM and SCCM detailing treatment recommendations for adults with sepsis, including antimicrobial therapy and management of fluids.
Caring for Pediatric Patients With Sepsis
This JAMA Clinical Guidelines Synopsis summarizes the updated 2026 clinical practice guideline on management of sepsis and septic shock in children from the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.
Diagnosis and Management of Resistant Hypertension – A Review
Hypertension, defined as office systolic blood pressure (SBP) 130 mm Hg or greater and/or diastolic blood pressure 80 mm Hg or greater, affects 43.9% of women and 49.5% of men in the US. Approximately 19.7% of patients treated for hypertension…
Management of Hypertension in Adults
This JAMA Clinical Guidelines Synopsis summarizes the American College of Cardiology/American Heart Association 2025 guideline on prevention, detection, evaluation, and management of hypertension in adults.
Treatment of Helicobacter pylori Infection
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterologyís 2024 guideline on treatment of Helicobacter pylori infection.
Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer – The ORCHESTRA Randomized Clinical Trial
Importance Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking. Objective To investigate whether tumor debulking added to palliative…
Peanut Allergy
This JAMA Insights discusses peanut allergy, including diagnosis, introduction of peanuts to infant diet, and immunotherapy options.
Obesity and Cancer – A Translational Science Review
Importance Obesity is associated with increased risk of cancer, including endometrial, esophageal, gastric, kidney, colorectal, liver, gallbladder, pancreas, prostate, postmenopausal breast, ovarian, and thyroid cancers. Overweight and obesity account for approximately 10% of new cancer diagnoses annually in the US and…
The Hochberg Procedure for the Comparison of Multiple End Points
This Guide to Statistics and Methods provides an overview of the Hochberg procedure, an effective tool for avoiding false-positive conclusions in clinical trials reporting multiple end points.
