Importance Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. Objective To determine whether referral to an exclusively artificial intelligence (AI)–led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds…
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
This JAMA Insights discusses the causes and treatment of dental caries in US adults as well as preventive measures for patients and medical and dental clinicians.
Importance Since 2021, there have been growing calls in the US to prohibit gender-affirming medical care (GAMC) for transgender and gender-diverse (TGD) minors (ie, <18 years). Supporters of these bans have argued the restrictions are necessary to protect TGD minors from…
Importance Chronic exposure to arsenic in drinking water has been associated with increased chronic disease mortality. However, there is limited evidence on associations between reduced exposure and mortality risk. Objective To examine whether reductions in arsenic exposure, measured using urinary arsenic levels,…
Importance Peripheral neuropathy, defined as damage to peripheral nerves, affects approximately 1% of adults worldwide. More than 200 causes of peripheral neuropathy exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair. Diabetes…
This JAMA Insights discusses the most effective pharmacological treatments for individuals experiencing perinatal depression.
This JAMA Insights discusses continuous glucose monitoring use among individuals with type 2 diabetes, including types of devices, evidence of effectiveness, and adverse effects and contraindications.
Approximately 27% of adults in the US and Canada report having ever used cannabis for medical purposes. An estimated 10.5% of the US population reports using cannabidiol (CBD), a chemical compound extracted from cannabis that does not have psychoactive…
Importance Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and economic burden. Glucagon-like peptide-1 therapies (GLP-1 therapies) provide clinically meaningful weight loss and broad metabolic benefits. In response to Member State requests, the…
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