Combining Medications With Bariatric Surgery to Treat Obesity
This JAMA Insights examines the efficacy, adverse effects, and best approach to combining metabolic and bariatric surgery with weight loss medications for the treatment of obesity.
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Toward a Safer World by 2040 – The JAMA Summit Report on Reducing Firearm Violence and Harms
Importance Since the start of the 21st century, more than 800 000 firearm deaths and more than 2 million firearm injuries have occurred in the US. All categories of firearm violence—homicide, suicide, unintentional—result in reverberating harms to individuals, families, communities, and society….
Classification and Risk Assessment of Chronic Kidney Disease
This JAMA Clinical Guidelines Synopsis summarizes KDIGOís 2024 clinical practice guideline for evaluation and management of chronic kidney disease.
Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia
Importance Persons with heterozygous familial hypercholesterolemia (HeFH) are at increased risk of atherosclerotic cardiovascular disease due to lifelong elevated levels of low-density lipoprotein cholesterol (LDL-C). Many patients with HeFH do not achieve guideline-recommended LDL-C goals with the currently available lipid-lowering therapies….
Coronary Computed Tomography Angiography in Prediction of First Coronary Events
Importance Risk stratification strategies in primary prevention of coronary events lack precision. Objective To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort…
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation – The DECAF Randomized Clinical Trial
Importance Conventional wisdom holds that caffeinated coffee is proarrhythmic. Coffee is the most commonly consumed caffeinated beverage in the US, and a randomized trial assessing caffeinated coffee consumption in patients with atrial fibrillation (AF) has not previously been performed. Objective To determine…
DASH-Patterned Groceries and Effects on Blood Pressure – The GoFresh Randomized Clinical Trial
Importance The Dietary Approaches to Stop Hypertension (DASH) eating plan lowered blood pressure (BP) among Black adults in a controlled environment, but to date, there are no grocery shopping strategies that replicated its health effects in a community setting. Objective The Groceries…
Primary Biliary Cholangitis
This JAMA Insights discusses the clinical presentation, diagnosis, and treatment of primary biliary cholangitis.
Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults
Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) includes a range of liver conditions, progressing from isolated steatosis (characterized by fat accumulation in the liver without inflammation) to metabolic dysfunction–associated steatohepatitis (MASH), which involves fat accumulation and inflammation in the liver. The…
An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program – A Randomized Clinical Trial
Importance Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. Objective To determine whether referral to an exclusively artificial intelligence (AI)–led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds…
