Microplastics and Human Health
This JAMA Insights discusses rising detection of microplastics in human tissue and the importance of international cooperation to limit plastic pollution.
JAMA
Painful Hand Swelling With Finger Contractures
A 56-year-old woman with no history of rheumatic disease or hand injury had swelling and tenderness of the bilateral wrists, metacarpophalangeal and proximal interphalangeal joints, nodular palmar tendon thickening, and flexion contractures of all fingers; results of serologic testing for…
Syphilis – A Review
Importance Syphilis is an infectious disease caused by Treponema pallidum, a gram-negative, spirochete bacterium. Worldwide, an estimated 8 million adults aged 18 to 49 years acquired syphilis in 2022. From 2019 to 2023, US syphilis cases increased by 61% overall, with diagnoses…
Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction
Importance Heart failure with preserved ejection fraction (HFpEF) is a major cause of hospitalization, often occurring in patients with cardiometabolic comorbidities such as obesity and type 2 diabetes. Although early trials of semaglutide and tirzepatide have shown promising results in improving…
Recurrent Clostridioides difficile Infections
This JAMA Insights discusses the epidemiology, diagnosis, and treatment of recurrent Clostridioides difficile infections.
A Direct-to-Patient Digital Health Program for Lung Cancer Screening – A Randomized Clinical Trial
Importance Screening chest computed tomography (CT) scans reduce lung cancer mortality in high-risk individuals, but less than 20% of eligible individuals are screened in the US. Objective To determine whether a direct-to-patient digital health program increases lung cancer screening. Design, Setting, and…
Lung Cancer in Nonsmoking Individuals – A Review
Lung cancer in nonsmoking individuals (defined as people who have smoked fewer than 100 cigarettes in their lifetime) accounts for 15% to 20% of all lung cancer cases worldwide. In the US, the annual incidence of lung cancer in nonsmoking…
Postpartum Hemorrhage
This JAMA Insights discusses risk factors for, assessment, and management of postpartum hemorrhage.
Bioresorbable vs Metallic Occluders for Transcatheter Atrial Septal Defect Closure – A Randomized Clinical Trial
Importance The permanent metallic occluders used for atrial septal defect (ASD) closure are associated with risks of late complications and may impede access to the left atrium. Bioresorbable occluders have the potential to address these limitations but have yet to be…
Closed-Loop Insulin Delivery in Type 1 Diabetes in Pregnancy – The CIRCUIT Randomized Clinical Trial
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
