Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture…
This JAMA Guide to Statistics and Methods article discusses designing and implementing clinical trials to minimize the number of missing data.
Importance Keratinocyte carcinomas are skin cancers that arise from keratinocytes and are composed of basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs). Keratinocyte carcinomas are common in North America, Australia, New Zealand, and Europe. Approximately 5.4 million keratinocyte carcinomas…
This JAMA Insights examines the efficacy, adverse effects, and best approach to combining metabolic and bariatric surgery with weight loss medications for the treatment of obesity.
Importance Since the start of the 21st century, more than 800 000 firearm deaths and more than 2 million firearm injuries have occurred in the US. All categories of firearm violence—homicide, suicide, unintentional—result in reverberating harms to individuals, families, communities, and society….
This JAMA Clinical Guidelines Synopsis summarizes KDIGOís 2024 clinical practice guideline for evaluation and management of chronic kidney disease.
Importance Persons with heterozygous familial hypercholesterolemia (HeFH) are at increased risk of atherosclerotic cardiovascular disease due to lifelong elevated levels of low-density lipoprotein cholesterol (LDL-C). Many patients with HeFH do not achieve guideline-recommended LDL-C goals with the currently available lipid-lowering therapies….
Importance Risk stratification strategies in primary prevention of coronary events lack precision. Objective To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort…
Importance Conventional wisdom holds that caffeinated coffee is proarrhythmic. Coffee is the most commonly consumed caffeinated beverage in the US, and a randomized trial assessing caffeinated coffee consumption in patients with atrial fibrillation (AF) has not previously been performed. Objective To determine…
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