Importance Up to 40% of men older than 50 years have lower urinary tract symptoms, including urinary urgency, nocturia, and weak urinary stream, due to disorders of the bladder and prostate. These symptoms negatively affect quality of life and may be…
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Kidney Disease: Improving Global Outcomes (KDIGO) recommendations for management and delaying progression of chronic kidney disease (CKD) in adults.
Importance Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US….
Importance Ovarian cancer is the eighth most common cause of cancer and cancer death in women worldwide. In 2022, ovarian cancer was diagnosed in approximately 324,398 individuals, and 206 839 died of ovarian cancer worldwide. In 2025, it is estimated that…
This JAMA Insights discusses evidence about the care of patients with firearm injury, including management of chronic pain, peripheral nerve injury, and lead toxicity from bullet fragments.
Importance Diverticulosis is defined by the presence of multiple outpouchings (diverticula) originating from the intestinal lumen. Diverticulitis is defined as inflammation of these diverticula. The annual incidence of diverticulitis in the US is approximately 180 per 100 000 people, resulting in approximately…
Importance A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the…
This JAMA Insights explores optimal strategies for managing the adverse effects associated with incretin-based medications for obesity, including semaglutide and tirzepatide.
This JAMA Insights explores strategies for effectively communicating a diagnosis of mild cognitive impairment or dementia to patients and their care partners.
A 34-year-old woman had recurrent episodes of crampy, diffuse abdominal pain not relieved by eating or defecation. Laboratory evaluation was unremarkable except for decreased C4 levels; abdominal computed tomography showed jejunal wall edema and ascites; and her father and brother…
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