JAMA

Essential Thrombocythemia – A Review

Importance  Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons. Observations  Patients with essential thrombocythemia have a persistent…

Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers – The IN-PEACE Randomized Clinical Trial

Importance  Care management benefits community-dwelling patients with dementia, but studies include few patients with moderate to severe dementia or from racial and ethnic minority populations, lack palliative care, and seldom reduce health care utilization. Objective  To determine whether integrated dementia palliative care…

A 58-Year-Old Woman With Urticaria, Fever, and Joint Pain

A 58-year-old woman with no allergies or rheumatic disease had a 2-year history of spontaneous wheals that occurred daily, accompanied by pruritus, arthralgia, and intermittent fevers; the wheals resolved after several hours without residual hyperpigmentation or bruising. C-reactive protein level…

Molecular Phenotyping With Proteomics

This JAMA Insights explores the capability of proteomics to analyze thousands of proteins in patient samples, which could improve clinicians’ understanding of and ability to treat a wide range of diseases.

Testicular Germ Cell Tumors – A Review

Importance  Testicular cancer is the most common solid malignancy among males aged 15 to 40 years in the US, with approximately 10 000 new cases diagnosed each year. Between 90% and 95% of testicular cancers are germ cell tumors (GCTs). Observations  The mean…

Patient-Clinician Communication About Weight Loss

This JAMA Insights explores effective communication strategies for clinicians who do not specialize in treating obesity in how to introduce conversations about weight loss with their patients and offer them support and treatment.