Importance Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US….
Importance Ovarian cancer is the eighth most common cause of cancer and cancer death in women worldwide. In 2022, ovarian cancer was diagnosed in approximately 324,398 individuals, and 206 839 died of ovarian cancer worldwide. In 2025, it is estimated that…
This JAMA Insights discusses evidence about the care of patients with firearm injury, including management of chronic pain, peripheral nerve injury, and lead toxicity from bullet fragments.
Importance Diverticulosis is defined by the presence of multiple outpouchings (diverticula) originating from the intestinal lumen. Diverticulitis is defined as inflammation of these diverticula. The annual incidence of diverticulitis in the US is approximately 180 per 100 000 people, resulting in approximately…
Importance A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the…
This JAMA Insights explores optimal strategies for managing the adverse effects associated with incretin-based medications for obesity, including semaglutide and tirzepatide.
This JAMA Insights explores strategies for effectively communicating a diagnosis of mild cognitive impairment or dementia to patients and their care partners.
A 34-year-old woman had recurrent episodes of crampy, diffuse abdominal pain not relieved by eating or defecation. Laboratory evaluation was unremarkable except for decreased C4 levels; abdominal computed tomography showed jejunal wall edema and ascites; and her father and brother…
Importance This article highlights key National Institutes of Health (NIH) programs, policies, and scientific advances that have informed and improved the health of women and describe the promise and potential of harnessing cutting-edge science and integrative approaches to advance women’s health…
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Society of Critical Care Medicine guidelines on use of corticosteroids in sepsis, acute respiratory distress syndrome, and community-acquired pneumonia.
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