Therapies to Decrease Severe Respiratory Syncytial Virus Illness
This JAMA Insights discusses the use of monoclonal antibodies or protein-based vaccines to help prevent severe RSV infection in infants, children, and older adults.
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Accounting for Competing Risks in Clinical Research
This JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research.
Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections – A Review
Importance Severe pulmonary infections, including COVID-19, community-acquired pneumonia, influenza, and Pneumocystis pneumonia, are a leading cause of death among adults worldwide. Pulmonary infections in critically ill patients may cause septic shock, acute respiratory distress syndrome, or both, which are associated with mortality rates…
Management of Depression in Adults – A Review
Importance Approximately 9% of US adults experience major depression each year, with a lifetime prevalence of approximately 17% for men and 30% for women. Observations Major depression is defined by depressed mood, loss of interest in activities, and associated psychological and somatic…
Interventions to Prevent Falls in Older Adults – Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance Falls are the most common cause of injury-related morbidity and mortality in older adults. Objective To systematically review evidence on the effectiveness and harms of fall prevention interventions in community-dwelling older adults. Data Sources MEDLINE, Cumulative Index for Nursing and Allied Health…
Interventions to Prevent Falls in Community-Dwelling Older Adults – US Preventive Services Task Force Recommendation Statement
Importance Falls are the leading cause of injury-related morbidity and mortality among older adults in the US. In 2018, 27.5% of community-dwelling adults 65 years or older reported at least 1 fall in the past year and 10.2% reported a fall-related…
Diagnosis and Management of Celiac Disease
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s 2023 guideline update on diagnosis and management of celiac disease.
Two-Stage Syphilis Testing
A 54-year-old woman presented with erythematous annular and indurated plaques on her face, trunk, and extremities and had false-positive syphilis test results during 2 pregnancies 25 and 22 years prior. What would you do next?
Perioperative Management of Antithrombotic Therapy
This JAMA Clinical Guidelines Synopsis summarizes the American College of Chest Physicians – 2022 guideline on perioperative management of patients taking oral anticoagulation or antiplatelet therapy who are undergoing an elective surgery or procedure.
Test-Negative Study Designs for Evaluating Vaccine Effectiveness
This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the…
