Use of Intravenous Albumin
This JAMA Clinical Guidelines Synopsis summarizes the 2024 guidelines on use of intravenous albumin from the International Collaboration for Transfusion Medicine.
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Antihypertensive Medication Timing and Cardiovascular Events and Death – The BedMed Randomized Clinical Trial
Importance Whether administration of blood pressure medications at bedtime instead of in the morning reduces cardiovascular risk is unknown, as findings from large clinical trials have not been consistent. There is also concern that bedtime antihypertensive use could induce glaucoma-related visual…
The Microbiome and Cancer – A Translational Science Review
Importance Growing evidence suggests that microbes located within the gastrointestinal tract and other anatomical locations influence the development and progression of diseases such as cancer. Observations Clinical and preclinical evidence suggests that microbes in the gastrointestinal tract and other anatomical locations, such…
Screening for Syphilis Infection During Pregnancy – US Preventive Services Task Force Reaffirmation Recommendation Statement
Importance Untreated syphilis infection during pregnancy can be passed to the fetus, causing congenital syphilis. Congenital syphilis is associated with premature birth, low birth weight, stillbirth, neonatal death, and significant abnormalities in the infant such as deformed bones, anemia, enlarged liver…
A Woman With Facial, Neck, and Chest Swelling During Dental Cleaning
A 37-year-old woman with no history of lung disease experienced sudden-onset tearing pain in her jaw several minutes into a routine air-powder dental polishing; chest radiography and computed tomography showed air located in the fascial planes of her neck and…
Immune Thrombotic Thrombocytopenic Purpura – A Review
Importance Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy that presents with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. Worldwide annual incidence of iTTP is 2 cases per million to 6 cases per million. Observations Immune TTP is caused by an…
Remestemcel-L-rknd for Steroid-Refractory Acute Graft-vs-Host Disease in Pediatric Patients
This JAMA Insights discusses the FDA approval of remestemcel-L-rknd to treat graft-vs-host disease in children and provides regulatory considerations for this approval.
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension – The KARDIA-2 Randomized Clinical Trial
Importance In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective To evaluate the efficacy and safety of zilebesiran…
Uveitis in Adults – A Review
Importance Uveitis is characterized by inflammation of the uvea—the middle portion of the eye composed of the iris, ciliary body, and choroid—causing eye redness, pain, photophobia, floaters, and blurred vision. Untreated uveitis may cause cataracts, glaucoma, macular edema, retinal detachment, optic…
A Woman With Headache, Fatigue, and Aphasia
A woman with no significant medical history had 3 days of headache, fatigue, and expressive aphasia; laboratory testing showed microangiopathic hemolytic anemia, increasing schistocytes on serial blood smears, diminished ADAMTS13 activity, and a high inhibitor titer. What is the diagnosis…
