Red Papulonodules in a Kidney Transplant Recipient
A man in his 60s who had a kidney transplant was taking mycophenolate mofetil, tacrolimus, and prednisone presented with painless lesions on the left upper extremity. What is your diagnosis?
Medical Knowledge
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury – The BICARICU-2 Randomized Clinical Trial
Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with day 90 all-cause mortality in patients with severe…
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock – The ANDROMEDA-SHOCK-2 Randomized Clinical Trial
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock – The ANDROMEDA-SHOCK-2 Randomized Clinical Trial
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture…
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Importance The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of…
Topical Anti-Inflammatory Treatments for Atopic Dermatitis
Clinical Question Which topical anti-inflammatory treatments are most effective and safe for managing atopic dermatitis? Bottom Line In a network meta-analyses, very potent/potent topical corticosteroids; tacrolimus, 0.1%; and topical Janus kinase inhibitors were among the most effective treatments for short-term control of…
Pattern-Mixture Models for Missing Data
This JAMA Guide to Statistics and Methods article discusses designing and implementing clinical trials to minimize the number of missing data.
Gingival Swelling and Frequent Epistaxis in an Older Woman
A 69-year-old woman was referred due to widespread gingival swelling, which had been worsening over the preceding 3 months and was unresponsive to antibiotic treatment. Gingival biopsy showed areas of chronic inflammation, microabscess foci, and pseudoepitheliomatous hyperplasia of the covering…
Keratinocyte Carcinoma – A Review
Importance Keratinocyte carcinomas are skin cancers that arise from keratinocytes and are composed of basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs). Keratinocyte carcinomas are common in North America, Australia, New Zealand, and Europe. Approximately 5.4 million keratinocyte carcinomas…
