A 60-year-old woman presented with progressive right lower extremity radiculopathy and numbness, a pigmented skin lesion on the right side of the chest, and right ankle jerk reflex. Magnetic resonance imaging of the lumbar spine revealed multiple intradural, contrast-enhancing lesions….
Importance Psoriasis is a chronic immune-mediated disease associated with cardiovascular, metabolic, musculoskeletal, psychiatric, hepatic, kidney, and pulmonary comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved by the US Food and Drug Administration for type 2 diabetes, obesity, cardiovascular risk…
A Black woman of Hispanic ethnicity with a history of hypertension, obesity, and headaches had symmetrically distributed, well-demarcated hyperpigmented lines that had developed during pregnancy and that extended from her buttocks to the lower extremities; physical examination was otherwise unremarkable….
A man in his 70s presented with a subcutaneous nodule with a central punctum on the left thigh and a dermal keratinizing cyst in continuity with the overlying epidermis. What is your diagnosis?
Importance The US Department of Veterans Affairs (VA) Whole Health approach was congressionally mandated in 2016 for patients with chronic pain receiving care in VA hospitals, but no randomized clinical trials have tested its benefits. Objective To evaluate the effectiveness…
Importance Children in the US are disproportionately affected by disasters. However, pediatric-specific disaster medicine research remains limited, underscoring an urgent need for a pediatric-focused disaster medicine research agenda for the US to improve outcomes and preparedness for future events. Objective …
This Clinical Insights summarizes the pharmacological characteristics of dalbavancin and oritavancin and evaluates the clinical evidence supporting their use in infections beyond acute bacterial skin and skin structure infections for general internal medicine clinicians.
Importance Heart failure (HF) affects more than 64 million individuals worldwide, and acute HF is associated with 1-year mortality rates of 23.6% in North America and Europe. Cardiac dyssynchrony from conduction system disease may cause HF progression, particularly in patients…
This JAMA Insights discusses the epidemiology, clinical presentation, and diagnostic evaluation of benign paroxysmal positional vertigo.
An 82-year-old man presented with 4 months of fluctuating diagonal binocular diplopia and progressive bilateral ptosis. Examination in the strabismus clinic revealed variable ptosis and ophthalmoplegia in multiple gaze directions, with a large-angle esotropia and left hypotropia. What would you…
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