Recurrent Clostridioides difficile Infections
This JAMA Insights discusses the epidemiology, diagnosis, and treatment of recurrent Clostridioides difficile infections.
Medical Knowledge
Diffuse Reversible Leukoencephalopathy in Intracranial Aspergillus Infection
This case report describes a patient who presented with a 2-day history of dizziness, unsteady gait, and confusion. In the past month, he had experienced 2 cerebral infarctions and fungal infection in his left armpit.
Higher-Valent Pneumococcal Conjugate Vaccines—Perspective for 2026
This Clinical Insights describes updated pneumococcal conjugate vaccines and their recommended use in adults.
The Harms of Inappropriate Food-Specific Immunoglobulin E TestingóLess Is More
This Teachable Moment describes a 56-year-old woman with a concern for a food allergy and bilateral leg muscle spasms.
A Direct-to-Patient Digital Health Program for Lung Cancer Screening – A Randomized Clinical Trial
Importance Screening chest computed tomography (CT) scans reduce lung cancer mortality in high-risk individuals, but less than 20% of eligible individuals are screened in the US. Objective To determine whether a direct-to-patient digital health program increases lung cancer screening. Design, Setting, and…
Lung Cancer in Nonsmoking Individuals – A Review
Lung cancer in nonsmoking individuals (defined as people who have smoked fewer than 100 cigarettes in their lifetime) accounts for 15% to 20% of all lung cancer cases worldwide. In the US, the annual incidence of lung cancer in nonsmoking…
Ambulate TID or Hospital-Acquired Disability (HAD)?
Why is it that individuals who are hospitalized often leave the hospital with decreased mobility and functional abilities? In this episode of Clinically Significantô, host Maylyn Martinez, MD, MSc explores the causes, diagnosis, and treatment of Hospital-acquired disability (HAD). Are…
Can AI Help Physicians Detect Sepsis?
Sepsis: at its inception, it is difficult to recognize but easy to treat; left unattended, it becomes easy to recognize and difficult to treat. As the adage states, sepsis is notoriously difficult to recognize in its early stages, due to…
Whole Child, Whole Health – Lessons Learned for Behavioral Health Integration in Pediatrics
Dr. Marian Earls, board-certified General and Developmental and Behavioral Pediatrician, and Chair of the AAP Mental Health Leadership Work Group for the American Academy of Pediatrics (AAP) discusses key learnings the AAP has garnered as a long-standing member of the…
Postpartum Hemorrhage
This JAMA Insights discusses risk factors for, assessment, and management of postpartum hemorrhage.
