AS-OCT Imaging of River Water Granuloma in a Child
This case report discusses a diagnosis of trematode granuloma in a child aged 8 years who presented with a painful red right eye after 2 weeks of river swimming.
Medical Knowledge
Prepregnancy Care and Counseling – A Review
Importance Prepregnancy care and counseling optimize maternal health before conception to improve outcomes for mothers and infants. In the US, 66.4% of reproductive-aged women have at least 1 modifiable risk factor for adverse pregnancy outcomes. Observations For all individuals desiring…
Interrupted Time Series Analysis for Policy Evaluation
This Guide to Statistics and Methods examines the population-level associations of guidelines for the use of doxycycline postexposure prophylaxis with sexually transmitted infection incidence.
Gastrojejunostomy Tube Intolerance
This Teachable Moment describes a patient who underwent a recent gastrojejunostomy tube placement, who returned to the hospital after 3 weeks with gastrointestinal distress and leakage at the insertion site.
Using Serious Games to Increase the Implementation of Trauma Triage Guidelines – A Randomized Clinical Trial
Importance Low-cost methods that improve physician adherence to clinical guidelines are lacking. Trauma triage exemplifies time-sensitive conditions where guideline adherence remains at 50% or less despite stakeholder efforts, particularly when treating older adults. Objective To determine whether a theory-based serious…
US Food and Drug Administration Sentinel Initiative and Postmarket Drug Safety Surveillance – A Review
Importance The US Food and Drug Administration (FDA) Sentinel Initiative’s Active Risk Identification and Analysis (ARIA) system enables medical product safety surveillance using a large, national distributed network of administrative claims and electronic health record data. As FDA increasingly emphasizes…
Outer Retinal Disruption in a Young Male
A 17-year-old male with a 3-month history of bilateral blurred vision and photophobia presents with placoid lesions in both eyes and further vision loss in the right eye. What would you do next?
Blinding Integrity in Psychedelic Randomized Clinical Trials – A Systematic Review
Importance Psychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity…
Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures – The TOBRA Randomized Clinical Trial
Importance Previous research has suggested that intrawound vancomycin powder reduces deep surgical site infections among patients with periarticular tibial fractures at high risk of infection. It is unknown whether the addition of tobramycin powder further decreases infection rates. Objective To…
International Eczema Council Definitions of Low Disease Activity and Remission in Atopic Dermatitis – A Consensus Statement
Importance Advances in targeted therapeutics have made substantial response states in atopic dermatitis (AD) increasingly attainable. However, the field lacks standardized, internationally endorsed definitions of low disease activity (LDA), very low disease activity (vLDA), and remission to benchmark treatment response,…
