Multimodal Imaging Insights Into Iatrogenic Cataract After Laser Vitreolysis
This case report discusses the use of swept-source optical coherence tomography to evaluate the location and morphology of lens lesions.
Medical Knowledge
Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy
Importance Colorectal cancer (CRC) risk among older adults with prior adenoma is uncertain. Objective To estimate cumulative CRC risks, non-CRC mortality, and all-cause mortality among adults 75 years of age or older with vs without adenoma at prior colonoscopy (in…
Reticulate Purpuric Macules of the Feet After Endovascular Aortic Repair
A man in his 70s with a history of hypertension, dyslipidemia, chronic obstructive pulmonary disease, and aortoiliac occlusive disease was admitted with a symptomatic impending rupture of a thoracic aortic aneurysm, followed by reticulate erythematous to violaceous macules that appeared…
Management of Crohn Disease in Adults
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterologyís 2025 recommendations on management of Crohn disease in adults.
Worldwide Seasonal Variation in Hospital Admissions for Diverticulitis – A Systematic Review
Importance Seasonal or climate variation is increasingly recognized as being associated with the incidence of several acute abdominal conditions, yet its role in diverticulitis remains uncertain. Understanding temporal trends may provide insight into modifiable environmental or behavioral risk factors and…
A Ketogenic Diet for Treatment-Resistant Depression – A Randomized Clinical Trial
Importance Preclinical evidence and case reports suggest potential therapeutic benefits of ketogenic diets (KDs) in the treatment of depression, but evidence from well-controlled randomized clinical trials (RCTs) is lacking. Objective To assess the efficacy of a KD compared with a…
Changes in Clinician Time Expenditure and Visit Quantity With Adoption of Artificial Intelligence–Powered Scribes
Importance Artificial intelligence (AI)–enabled scribes have been proposed to reduce electronic health record (EHR) burden and improve clinician satisfaction. There is limited evidence about their associated results across multiple sites and relative benefits for different clinician groups. Objective To assess…
Rapid Methadone Titration for Opioid Withdrawal Management
This Teachable Moment describes how traditional titration protocols for patients with fentanyl use disorder may be inadequate for patients with frequent, high-dose, or high-potency opioid use.
Does This Child Have a Concussion? – The Rational Clinical Examination Systematic Review
Importance Concussion is a mild traumatic brain injury with associated abnormalities in brain function, rather than structural injury. An estimated 1.1 million to 1.9 million pediatric concussions occur annually in the US. Objective To determine the accuracy of clinical history…
Management of Orthostatic Hypotension – A Review
Importance Orthostatic hypotension is a common but underrecognized condition that increases with age and is associated with a lower quality of life, falls, and increased mortality. The frequent coexistence of supine hypertension and postprandial hypotension with orthostatic hypotension makes it…
