Active Comparator New User Cohort Studies and Matching
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching.
Medical Knowledge
Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults
Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) includes a range of liver conditions, progressing from isolated steatosis (characterized by fat accumulation in the liver without inflammation) to metabolic dysfunction–associated steatohepatitis (MASH), which involves fat accumulation and inflammation in the liver. The…
An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program – A Randomized Clinical Trial
Importance Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. Objective To determine whether referral to an exclusively artificial intelligence (AI)–led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds…
Closed-Loop Insulin Delivery in Type 1 Diabetes in Pregnancy – The CIRCUIT Randomized Clinical Trial
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
Microplastics Infiltrate Our Bodies. How Can Physicians Help?
When plastic breaks down into microplastic particles, they pollute the environment and numerous studies have found they infiltrate multiple organ systems and tissues. In fact, a 2022 study in Environmental International estimated that microplastics were circulating in the blood of…
Microplastics Infiltrate Our Bodies. How Can Physicians Help?
When plastic breaks down into microplastic particles, they pollute the environment and numerous studies have found they infiltrate multiple organ systems and tissues. In fact, a 2022 study in Environmental International estimated that microplastics were circulating in the blood of…
Human-Centered Health Care – Designing Systems for Physician Well-Being
Dr Heather Farley, AMA Vice President of Professional Satisfaction, joins Dr Elizabeth Harry, chief well-being officer at Michigan Medicine, Carolyn Winslow, PhD, organizational research psychologist and well-being research & analytics lead at the Michigan Medicine Office of Well-Being, and Ken…
One Federally Qualified Health Center’s Journey to Joy in Medicine
Dr Mark Schildt, Chief Wellness Officer at El Rio Health, shares how they became the first Federally Qualified Health Center (FQHC) to earn Gold-level recognition from the American Medical Association’s Joy in MedicineÆ Program in 2024. He describes El Rio’s…
Multiple Papules and Nodules on the Face and Extremities
A woman and avid gardener in her 70s with rheumatoid arthritis who was receiving long-term immunosuppression presented with a 6-month history of progressive papulonodules on her face and extremities. What is your diagnosis?
Pott Puffy Tumor
This case report describes a soft, warm, dome-shaped, erythematous, nontender nodule on the forehead.
