This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an…
Importance Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common. Observations Primary adrenal…
Importance Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories. Objectives To…
This JAMA Insights proposes solutions to help reduce the risk of heat-related illnesses among workers.
This JAMA Clinical Guidelines Synopsis summarizes the 2025 Global Strategy for the Diagnosis, Management, and Prevention of COPD.
Importance Type 2 diabetes involves progressive loss of insulin secretion from pancreatic β cells in the setting of insulin resistance and manifests clinically as hyperglycemia. Type 2 diabetes accounts for 90% to 95% of all cases of diabetes globally, with estimates…
Importance Intimate partner violence (IPV) and caregiver abuse of older or vulnerable adults are common and cause significant morbidity. Objective To review the evidence on screening and interventions for IPV and caregiver abuse among adults. Data Sources PubMed, Cochrane Library, and EMBASE through…
Importance Intimate partner violence (IPV) affects millions of US residents across the lifespan and is often unrecognized. Abuse of older or vulnerable adults by a caregiver or someone else they may trust is common and can result in significant injury, death,…
A 34-year-old woman had progressive skin tightening over her right elbow and forearm, bilateral forearm pain, difficulty extending her fingers and elbows, and elevated eosinophil count and C-reactive protein level; examination showed a linear depression along a superficial vein when…
Importance Osteoporosis is characterized by low bone mass, increased bone fragility, and increased susceptibility to fracture, which is associated with substantial morbidity, mortality, and economic costs. Worldwide, 1 in 3 women and 1 in 5 men older than 50 years of…
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