This JAMA Insights discusses the FDA approval of remestemcel-L-rknd to treat graft-vs-host disease in children and provides regulatory considerations for this approval.
Importance In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective To evaluate the efficacy and safety of zilebesiran…
Importance Uveitis is characterized by inflammation of the uvea—the middle portion of the eye composed of the iris, ciliary body, and choroid—causing eye redness, pain, photophobia, floaters, and blurred vision. Untreated uveitis may cause cataracts, glaucoma, macular edema, retinal detachment, optic…
A woman with no significant medical history had 3 days of headache, fatigue, and expressive aphasia; laboratory testing showed microangiopathic hemolytic anemia, increasing schistocytes on serial blood smears, diminished ADAMTS13 activity, and a high inhibitor titer. What is the diagnosis…
Importance Platelet transfusion is a frequent procedure with benefits and risks. Objective To provide recommendations in adult and pediatric populations in whom platelet transfusions are commonly performed. Evidence Review Grading of Recommendations Assessment Development and Evaluation (GRADE) methodology was applied to findings from…
This JAMA Insights explores the spread of harmful algal blooms due to climate change and how exposure to toxic algae can negatively affect human health.
This JAMA Insights offers evidence-based communication strategies for addressing patient treatment expectations, which can improve outcomes and reduce adverse effects.
This JAMA Insights discusses trauma-informed care practices that can help clinicians provide sensitive and supportive care that may improve health outcomes in patients with a history of trauma.
Importance Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related to fetal hypoxia during labor is uncertain. Objective To compare the effectiveness of intrapartum maternal oral sildenafil citrate vs placebo in improving perinatal outcomes potentially related to…
Importance Guidelines recommend augmenting enteral protein during critical illness, but the impact on patient outcomes is uncertain. Objective To determine whether augmenting enteral protein increases days alive and free from hospitalization. Design, Setting, and Participants This cluster randomized, crossover, open-label trial recruited critically…
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