Climate Change, Marine Pathogens, and Human Health
This JAMA Insights explores the spread of harmful algal blooms due to climate change and how exposure to toxic algae can negatively affect human health.
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Improving Patients’ Treatment Expectations
This JAMA Insights offers evidence-based communication strategies for addressing patient treatment expectations, which can improve outcomes and reduce adverse effects.
Trauma-Informed Care
This JAMA Insights discusses trauma-informed care practices that can help clinicians provide sensitive and supportive care that may improve health outcomes in patients with a history of trauma.
Intrapartum Sildenafil to Improve Perinatal Outcomes – A Randomized Clinical Trial
Importance Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related to fetal hypoxia during labor is uncertain. Objective To compare the effectiveness of intrapartum maternal oral sildenafil citrate vs placebo in improving perinatal outcomes potentially related to…
Augmented Enteral Protein During Critical Illness – The TARGET Protein Randomized Clinical Trial
Importance Guidelines recommend augmenting enteral protein during critical illness, but the impact on patient outcomes is uncertain. Objective To determine whether augmenting enteral protein increases days alive and free from hospitalization. Design, Setting, and Participants This cluster randomized, crossover, open-label trial recruited critically…
Tipping Point Analysis – Assessing the Potential Impact of Missing Data
This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an…
Adrenal Insufficiency in Adults – A Review
Importance Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common. Observations Primary adrenal…
Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths
Importance Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories. Objectives To…
Occupational Heat-Related Illness
This JAMA Insights proposes solutions to help reduce the risk of heat-related illnesses among workers.
Inhaled Pharmacotherapy for Stable COPD
This JAMA Clinical Guidelines Synopsis summarizes the 2025 Global Strategy for the Diagnosis, Management, and Prevention of COPD.
