Importance Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking. Objective To investigate whether tumor debulking added to palliative…
This JAMA Insights discusses peanut allergy, including diagnosis, introduction of peanuts to infant diet, and immunotherapy options.
Importance Obesity is associated with increased risk of cancer, including endometrial, esophageal, gastric, kidney, colorectal, liver, gallbladder, pancreas, prostate, postmenopausal breast, ovarian, and thyroid cancers. Overweight and obesity account for approximately 10% of new cancer diagnoses annually in the US and…
This Guide to Statistics and Methods provides an overview of the Hochberg procedure, an effective tool for avoiding false-positive conclusions in clinical trials reporting multiple end points.
Importance Antidepressants for moderate to severe major depressive disorder may be discontinued prematurely because the prescribed antidepressant is not always the most appropriate medication for an individual. Guidelines have recommended more precise targeting of antidepressant treatment. Objective To evaluate the efficacy of…
This JAMA Insights explores how using numerical comparisons during patient-clinician encounters can help patients better understand their clinical situation and inform their decision-making.
Importance Chronic diarrhea is defined as loose or watery stools lasting longer than 4 weeks and affects approximately 6% to 7% of adults in the US. More than 90% of patients with chronic diarrhea have a noninfectious etiology. Observations The most common…
This JAMA Clinical Guidelines Synopsis summarizes the American Society of Clinical Oncologyís 2025 updated recommendations on fertility preservation in people with cancer.
This JAMA Insights discusses current evidence about risks to the health of pregnant individuals from ambient heat (hot weather, high indoor temperatures, and occupational exposures) and how these risks can be managed.
Importance In recent decades, there has been marked worldwide growth in diagnostic testing for coronary artery disease (CAD), with several common imaging modalities exposing patients to ionizing radiation. Objective To examine worldwide radiation doses for patients undergoing noninvasive CAD diagnostic testing. Design,…
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