Importance Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and economic burden. Glucagon-like peptide-1 therapies (GLP-1 therapies) provide clinically meaningful weight loss and broad metabolic benefits. In response to Member State requests, the…
This JAMA Insights explores how climate change could lead to increased incidence of allergic rhinitis and chronic rhinosinusitis due to such factors as air pollution and pollen levels.
A previously healthy man had headache, chest pain, abdominal pain, vomiting, and diarrhea 1 hour after eating raw tuna sashimi. His blood pressure was 67/42 mm Hg, and he had an erythematous nonpruritic rash on his upper torso, ST-segment elevation…
Importance Head and neck cancer, which arises in the lining or mucosa of the upper aerodigestive tract, specifically the oral cavity, oropharynx, larynx, hypopharynx, and paranasal sinuses, is the seventh most common cancer worldwide. In 2024, approximately 71 110 individuals in the…
This Guide to Statistics and Methods provides an overview of using observational data and reinforcement learning strategies to develop dynamic treatment regimes for patients who are critically ill.
A patient receiving adalimumab for rheumatoid arthritis had ulcerated plaques on the anterior and lateral aspects of the neck, upper chest, and nape and erythroderma on the dorsum of the hands, corresponding to areas of sun exposure, as well as…
Importance Globally, 968 350 new cases and 659 853 deaths from gastric cancer were reported in 2022. In the US, 30 300 new cases and 10 780 deaths were estimated in 2025. Observations Gastric cancer is more common in men, and the median age at diagnosis…
This JAMA Insights discusses postñintensive care unit syndrome, including how it is assessed and diagnosed as well as suggestions for treatment and prevention.
This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.
This JAMA Insights focuses on stillbirth, including causes, risk factors, and prenatal preventive care.
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