Importance Drug shortages are a persistent public health issue that increased during the COVID-19 pandemic. Both the US and Canada follow similar regulatory standards and require reporting of drug-related supply chain issues that may result in shortages. However, it is unknown…
Importance Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall…
A 30-year-old nulliparous woman with obesity and history of migraines and depression had 1 month of daily headaches, transient bilateral visual blurring, persistent vision loss in the temporal region of one eye, pulsatile tinnitus, and mild bilateral papilledema. What is…
Importance Inferior vena cava filters (IVCFs) are commonly used to prevent pulmonary embolism in selected clinical scenarios, despite limited evidence to support their use. Current recommendations from professional societies and the US Food and Drug Administration endorse timely IVCF retrieval when…
This JAMA Insights discusses the important role that interpreters play in facilitating communication between patients with limited English-language proficiency and their health care team and provides steps that can be taken to improve communication with remote interpreters for patients.
Importance Calcific aortic stenosis (AS) restricts the aortic valve opening during systole due to calcification and fibrosis of either a congenital bicuspid or a normal trileaflet aortic valve. In the US, AS affects 1% to 2% of adults older than 65…
This JAMA Clinical Guidelines Synopsis summarizes the 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation.
Importance Polycythemia vera (PV), a myeloproliferative neoplasm characterized by an increased red blood cell mass and increased risk of thrombosis, affects approximately 65 000 people in the US, with an annual incidence of 0.5 to 4.0 cases per 100 000 persons. Observations Erythrocytosis (hemoglobin…
This JAMA Insights explores how clinicians can use the harm reduction communication framework to engage with patients who have opioid use disorder, which could help prevent overdose and other substance use related harms.
This JAMA Insights explores harm reduction strategies for people who use drugs and the clinicians who treat them to help reduce the risk of unintentional drug overdose and infection.
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