Importance Previous studies on the comparative effectiveness between buprenorphine and methadone provided limited evidence on differences in treatment effects across key subgroups and were drawn from populations who use primarily heroin or prescription opioids, although fentanyl use is increasing across North…
Importance With the increase in trials assessing comparative effectiveness of approved products and alternative care strategies, guidance is needed to ensure ethical oversight is fit for purpose for the risks, burdens, and constraints on choice this research presents. Observations US regulations governing…
Importance In the US, many patients struggle to afford prescription drugs, leading to adverse health outcomes. To improve cost-related medication nonadherence, prescribers and clinical staff must understand how to assist patients in overcoming high prescription drug costs. Observations We reviewed the benefits…
A healthy 9-year-old had 10 days of nonproductive cough without fever, wheeze, chest pain, or abdominal pain but with diminished breath sounds in the right lower lung field. Results of laboratory testing were unremarkable; computed tomography revealed a fat-density mass…
This JAMA Insights examines the treatment and rising prevalence of anal cancer in the US in high-risk groups, including people with HIV and immunosuppression associated with solid organ transplant.
Importance Patient to staff ratios vary across US dialysis facilities and have been associated with patient outcomes in older adults. Objective To determine whether patient to nurse or patient to social worker staff ratios are associated with access to kidney transplant for…
Importance In the US, peptic ulcer disease affects 1% of the population and approximately 54 000 patients are admitted to the hospital annually for bleeding peptic ulcers. Observations Approximately 10% of patients presenting with upper abdominal pain in a primary care setting have…
This JAMA Insights discusses ovarian aging and provides strategies to address infertility due to ovarian aging.
Importance Drug shortages are a persistent public health issue that increased during the COVID-19 pandemic. Both the US and Canada follow similar regulatory standards and require reporting of drug-related supply chain issues that may result in shortages. However, it is unknown…
Importance Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall…
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