Eastern Equine Encephalitis in the US
This JAMA Insights examines the epidemiology, diagnosis, and management of eastern equine encephalitis virus disease in the US following a recent increase in reported cases.
JAMA
A 25-Year-Old With Palpitations, Fatigue, and Migraines
A woman had palpitations, fatigue, and worsening migraines. Plasma normetanephrine concentration was elevated, plasma metanephrine concentration was within reference range, and abdominal magnetic resonance imaging showed a left infrarenal para-aortic mass. What is the diagnosis and what would you do…
Lower Urinary Tract Symptoms in Men – A Review
Importance Up to 40% of men older than 50 years have lower urinary tract symptoms, including urinary urgency, nocturia, and weak urinary stream, due to disorders of the bladder and prostate. These symptoms negatively affect quality of life and may be…
Delaying Progression of Chronic Kidney Disease
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Kidney Disease: Improving Global Outcomes (KDIGO) recommendations for management and delaying progression of chronic kidney disease (CKD) in adults.
Early-Onset Gastrointestinal Cancers – A Review
Importance Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US….
Ovarian Cancer – A Review
Importance Ovarian cancer is the eighth most common cause of cancer and cancer death in women worldwide. In 2022, ovarian cancer was diagnosed in approximately 324,398 individuals, and 206 839 died of ovarian cancer worldwide. In 2025, it is estimated that…
Sequelae and Care After Firearm Injury
This JAMA Insights discusses evidence about the care of patients with firearm injury, including management of chronic pain, peripheral nerve injury, and lead toxicity from bullet fragments.
Diverticulitis – A Review
Importance Diverticulosis is defined by the presence of multiple outpouchings (diverticula) originating from the intestinal lumen. Diverticulitis is defined as inflammation of these diverticula. The annual incidence of diverticulitis in the US is approximately 180 per 100 000 people, resulting in approximately…
Patent Foramen Ovale and Stroke – A Review
Importance A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the…
Managing Adverse Effects of Incretin-Based Medications for Obesity
This JAMA Insights explores optimal strategies for managing the adverse effects associated with incretin-based medications for obesity, including semaglutide and tirzepatide.
