JAMA

Harm Reduction Strategies for People Who Use Drugs

This JAMA Insights explores harm reduction strategies for people who use drugs and the clinicians who treat them to help reduce the risk of unintentional drug overdose and infection.

Differential Legal Protections for Biologics vs Small-Molecule Drugs in the US

Importance  Biologics approved by the US Food and Drug Administration (FDA) receive 12 years of guaranteed protection from biosimilar competition compared with 5 years of protection from generic competition for new small-molecule drugs. Under the 2022 Inflation Reduction Act, biologics are…

Dengue

This JAMA Insights explores several aspects of dengue virus infection, including epidemiology, diagnosis, and clinical management, following a global resurgence in both endemic and nonendemic regions.

Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society–USA Panel

Importance  New data and new antiretroviral drugs and formulations continue to become available for the prevention and management of HIV infection. Objective  To provide updated recommendations for HIV treatment and clinical management and HIV prevention. Methods  A panel of volunteer expert physician scientists…

Axial Spondyloarthritis – A Review

Importance  Axial spondyloarthritis is an immune-mediated inflammatory condition involving the sacroiliac joints, spine, and peripheral joints. It affects approximately 1% of adults in the US and is associated with impaired physical function and reduced quality of life. Observations  Inflammatory chronic back pain…

Allogeneic Stem Cell Donation

This JAMA Insights discusses allogenic stem cell donation, including the donation process and the effects of stem cell donation on donors.

Atrial Fibrillation – A Review

Importance  In the US, approximately 10.55 million adults have atrial fibrillation (AF). AF is associated with significantly increased risk of stroke, heart failure, myocardial infarction, dementia, chronic kidney disease, and mortality. Observations  Symptoms of AF include palpitations, dyspnea, chest pain, presyncope, exertional…

Adolescent-Centered Sexual and Reproductive Health Communication

This JAMA Insights explores how clinicians can effectively communicate person-centered health care information to adolescents regarding sexual and reproductive health, contraception, and sexually transmitted infection testing and treatment.