Importance Persons with heterozygous familial hypercholesterolemia (HeFH) are at increased risk of atherosclerotic cardiovascular disease due to lifelong elevated levels of low-density lipoprotein cholesterol (LDL-C). Many patients with HeFH do not achieve guideline-recommended LDL-C goals with the currently available lipid-lowering therapies….
Importance Risk stratification strategies in primary prevention of coronary events lack precision. Objective To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort…
Importance Conventional wisdom holds that caffeinated coffee is proarrhythmic. Coffee is the most commonly consumed caffeinated beverage in the US, and a randomized trial assessing caffeinated coffee consumption in patients with atrial fibrillation (AF) has not previously been performed. Objective To determine…
Importance The Dietary Approaches to Stop Hypertension (DASH) eating plan lowered blood pressure (BP) among Black adults in a controlled environment, but to date, there are no grocery shopping strategies that replicated its health effects in a community setting. Objective The Groceries…
This case report describes a patient with left-sided weakness following transient ischemic attacks who underwent external carotid angioplasty based on findings from ultrahigh-resolution photon-counting computed tomographic angiography (CTA).
This JAMA Insights discusses the clinical presentation, diagnosis, and treatment of primary biliary cholangitis.
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching.
Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) includes a range of liver conditions, progressing from isolated steatosis (characterized by fat accumulation in the liver without inflammation) to metabolic dysfunction–associated steatohepatitis (MASH), which involves fat accumulation and inflammation in the liver. The…
Importance Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. Objective To determine whether referral to an exclusively artificial intelligence (AI)–led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds…
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
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