Importance Idiopathic normal pressure hydrocephalus (iNPH) is a progressive neurological disorder characterized by cerebral ventricular enlargement that is typically associated with gait impairment and often urinary dysfunction and cognitive decline in older adults. iNPH prevalence is approximately 1% to 4%…
This case report describes a patient in their 70s initially diagnosed with cerebral amyloid angiopathy whose diagnosis was challenged with repeat magnetic resonance imaging, which revealed arterialized left temporal cortical vein with an adjacent venous aneurysm.
Importance The Joint Commission requires hospitals and behavioral health care organizations to identify patients at risk of suicide (National Patient Safety Goal 15.01.01). Risk algorithms and in-person screening for suicide risk show utility in identifying patients at risk of suicidal…
This toolkit is a primer on PlanDoStudyAct, an iterative quality improvement method that can be applied to projects of varied scope and scale. It is relevant to practices, health systems, or individual teams looking to save time, improve culture, and…
Importance The Joint Commission recommends universal suicide screening in emergency departments (EDs), which emphasizes the need to identify at-risk individuals. Existing suicide risk prediction models rely primarily on clinical data and demonstrate limited performance. The potential of incorporating psychosocial information…
In recognition of National Physician Suicide Awareness Week, join us for a 90-minute session focused on dismantling the cultural barriers that prevent physicians and care teams from seeking mental health support.
Importance Women with HIV experience high rates of trauma, chronic stress, and depression, which are linked to cognitive impairment. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoid receptor function, inflammation, and HIV persistence are candidate mechanisms, yet no interventions directly target…
Importance Gestational diabetes is associated with future cardiometabolic risk, but postpartum evidence across the cardiovascular-kidney-metabolic (CKM) disorder spectrum remains limited. Objective To characterize the timing and magnitude of incident postpartum CKM disorders after a pregnancy complicated by gestational diabetes. Design,…
Importance Genetic ancestry may complement biological, behavioral, and clinical factors in understanding colorectal cancer (CRC) disparities; yet, ancestry-informed analyses in CRC remain limited. Objective To characterize associations of genetic ancestry with CRC burden, age at diagnosis, and age-specific risk, and…
This nonrandomized clinical trial assesses the safety and efficacy of darolutamide, with or without concomitant lipid-modifying agents (LMAs), in treating nonmetastatic castration-resistant prostate cancer.
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