Primary Biliary Cholangitis
This JAMA Insights discusses the clinical presentation, diagnosis, and treatment of primary biliary cholangitis.
Journal-based
Active Comparator New User Cohort Studies and Matching
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching.
Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults
Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) includes a range of liver conditions, progressing from isolated steatosis (characterized by fat accumulation in the liver without inflammation) to metabolic dysfunction–associated steatohepatitis (MASH), which involves fat accumulation and inflammation in the liver. The…
An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program – A Randomized Clinical Trial
Importance Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. Objective To determine whether referral to an exclusively artificial intelligence (AI)–led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds…
Closed-Loop Insulin Delivery in Type 1 Diabetes in Pregnancy – The CIRCUIT Randomized Clinical Trial
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
Multiple Papules and Nodules on the Face and Extremities
A woman and avid gardener in her 70s with rheumatoid arthritis who was receiving long-term immunosuppression presented with a 6-month history of progressive papulonodules on her face and extremities. What is your diagnosis?
Pott Puffy Tumor
This case report describes a soft, warm, dome-shaped, erythematous, nontender nodule on the forehead.
Dental Caries in Adults
This JAMA Insights discusses the causes and treatment of dental caries in US adults as well as preventive measures for patients and medical and dental clinicians.
A 13-Year-Old Male With Parotid Region Mass
A 13-year-old male presented with a 7-month history of a painless, progressively enlarging mass in the right parotid region. What is your diagnosis?
Large Choroidal Excavation in Stargardt Disease
This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood.
