Importance Excess body weight, which is associated with poor survival after breast cancer (BC) diagnosis, is a heritable trait. Objective To investigate whether genetic predisposition to excess body weight is associated with the risk of mortality among BC survivors. Design,…
Hypertension, defined as office systolic blood pressure (SBP) 130 mm Hg or greater and/or diastolic blood pressure 80 mm Hg or greater, affects 43.9% of women and 49.5% of men in the US. Approximately 19.7% of patients treated for hypertension…
Importance Hypertension significantly increases the risk of cardiovascular diseases (CVDs) and related cardiometabolic conditions, yet the role of healthy lifestyle in modifying these risks remains underexplored. Objective To investigate associations of adherence to healthy lifestyle before and after a hypertension…
Importance Colorectal cancer liver metastases (CRLM) are a common manifestation of colorectal cancer, and clinical decision-making for these patients is complex. The timing of CRLM detection, defined as synchronous, early metachronous, or late metachronous, is hypothesized to influence survival outcomes,…
Importance Methadone, a medication for opioid use disorder, is underused in the US response to the opioid overdose crisis. Under federal law, methadone can be offered in pharmacies via medication units, although a change to federal statutes or regulations could…
Importance Hydralazine is a selectively used cardiovascular medication with case reports and case series demonstrating an association between the use of hydralazine and antineutrophil cytoplasmic antibody–associated vasculitis. Objective To assess the risk of vasculitis associated with hydralazine use compared with…
Importance Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major factor underlying US health care costs. While its clinical burden is well documented, the full economic impact of AF—particularly among working-age adults with productivity losses—remains underexplored….
Importance Physical disability reflects the cumulative burden of chronic conditions. Although generally progressive, episodes of disability can be followed by periods of recovery; therefore, there is a need to identify modifiable risk factors that contribute to the dynamic development of…
Importance The demands of clinical practice have contributed to widespread burnout among health care professionals. Thus, there is an urgent need for scalable and evidence-based interventions to address burnout in this population. Objective To assess whether participation in an asynchronous,…
Importance Cancer is the leading cause of death for Latino and Latina individuals in the US. Lack of insurance is one of the leading contributing factors to low prevalence of colorectal cancer screening. In 2021, the state Medicaid coverage programs…
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