Journal-based

What Are the Most Ethically Salient Implications of Epigenetic Age Testing?

This commentary on a case considers how clinicians should help patients interpret results of tests that might be personally meaningful but not clinically actionable. Tests of biological age, for example, can easily lead to patient misunderstandings that can increase risks…

World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults

Importance  Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and economic burden. Glucagon-like peptide-1 therapies (GLP-1 therapies) provide clinically meaningful weight loss and broad metabolic benefits. In response to Member State requests, the…

Global Incidence of Pertussis After the COVID-19 Pandemic

Importance  Pertussis, or whooping cough, is caused by the Bordetella pertussis bacterium. It induces prolonged cough in all age groups and is a severe, life-threatening disease in young infants. Observations  In an online workshop organized by the International Bordetella Society on November 12, 2024,…

Lifestyle Interventions Addressing Blood Pressure in Children – A Systematic Review

Importance  The prevalence of high blood pressure in children is increasing, with health consequences reaching into adulthood. Individual-level interventions may help address the burden of high blood pressure at a population level, but there is less evidence from pediatric settings. Objective  To…

Kelch-Like Protein 11 Antibody-Associated Paraneoplastic Encephalitis

This case report describes a unique presentation of Kelch-like protein 11 antibody-associated paraneoplastic encephalitis in an 81-year-old woman with a high-grade neuroendocrine carcinoma consistent with metastatic Merkel cell carcinoma.

An Unexpected Cause of Hypotension

This Teachable Moment discusses a case of hypotension caused by severe adrenal insufficiency in a man in his 70s.

Probability, Probability-Based, and Nonprobability Surveys in Psychiatric Epidemiological Research

Importance  As mental health challenges continue to increase globally, using rigorous surveillance frameworks is essential for delivering nuanced population-level insights and informing evidence-based policy decisions. Objective  To develop a standard for using nonprobability and probability-based online panel surveys in psychiatric epidemiological research….

Climate Change, Allergic Rhinitis, and Sinusitis

This JAMA Insights explores how climate change could lead to increased incidence of allergic rhinitis and chronic rhinosinusitis due to such factors as air pollution and pollen levels.

Axenfeld-Rieger Syndrome in an Infant

This case report discusses a diagnosis of Axenfeld-Rieger syndrome in an 8-month-old infant who presented with bilateral abnormal pupils, posterior embryotoxon, and dental abnormalities.