Journal-based

Systemic Pharmacological Treatments for Chronic Plaque Psoriasis

Clinical Question  Among adults with moderate to severe plaque psoriasis, how do systemic treatments compare in attaining a Psoriasis Area and Severity Index 90 (PASI 90) response and the occurrence of serious adverse events? Bottom Line  Biologic therapies, particularly interleukin…

Prevalence of Central Sensitization in Postural Tachycardia Syndrome

Importance  A previous study showed a high prevalence of central sensitization syndrome (CSS) in patients with autonomic symptoms. The prevalence of CSS in postural tachycardia syndrome (POTS), a form of dysautonomia, is unknown. Objectives  To analyze the prevalence of CSS…

Opportunistic Genomic Screening for Familial Hypercholesterolemia to Improve Low-Density Lipoprotein Cholesterol – A Randomized Clinical Trial

Importance  The clinical benefit of opportunistic genomic screening for familial hypercholesterolemia (FH) has not been demonstrated in a randomized clinical trial (RCT). Objective  To evaluate the impact of returning clinically confirmed FH-associated genetic results on low-density lipoprotein cholesterol (LDL-C) levels….

Metformin, Maternal Glycemic Control, and Neonatal Hypoglycemia After Antenatal Steroids – A Randomized Clinical Trial

Importance  Although betamethasone reduces complications of prematurity, it can cause maternal hyperglycemia and neonatal hypoglycemia. Metformin effectively treats maternal hyperglycemia and has been shown to decrease neonatal hypoglycemia in women with gestational diabetes. Objective  To evaluate the impact of metformin…