This JAMA Insights discusses the US Food and Drug Administration approval of Kebilidi, eladocagene exuparvovec, for the treatment of aromatic L-amino acid decarboxylase deficiency in adult and pediatric patients.
This JAMA Insights explores the use of portable point-of-care ultrasound and focused cardiac ultrasound imaging in the diagnosis and treatment of patients with sepsis and septic shock in the emergency department and intensive care unit.
Importance Chronic myeloid leukemia (CML) has an annual incidence of 2 cases per 100 000 people and is newly diagnosed in approximately 9300 individuals per year in the US. Approximately 150 000 people in the US and 5 million worldwide have CML. Observations Chronic…
This JAMA Insights discusses how physicians can engage in successful clinical negotiation if a patient requests a test or treatment that is deemed inappropriate, potentially harmful, or low-value.
This JAMA Insights discusses recommendations for reducing the effects of surgical care on carbon emissions, including pre-, intra-, and postoperative changes to routine practices.
This JAMA Insights explores the use of different types of peripheral nerve blocks as an opioid-sparing pain strategy in the treatment of adults with hip fractures.
Importance Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and is the most common inherited kidney disorder worldwide. ADPKD accounts for 5% to 10% of kidney failure in the US and Europe, and its prevalence…
Importance Absolute iron deficiency, defined as low iron stores with or without anemia, affects approximately 2 billion people worldwide and 14% of adults in the US. Iron-deficiency anemia, defined as low hemoglobin due to low iron stores, affects approximately 1.2 billion…
Importance Small cell lung cancer (SCLC) is a high-grade neuroendocrine carcinoma with an incidence of 4.7 cases per 100 000 individuals in 2021 in the US and a 5-year overall survival of 12% to 30%. Observations Cigarette smoking is the primary risk factor…
Importance More than 3.5 million people worldwide and 540 000 individuals in the US receive maintenance hemodialysis or peritoneal dialysis for the treatment of chronic kidney failure. The 5-year survival rate is approximately 40% after initiation of maintenance dialysis. Observations Hemodialysis and peritoneal…
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