Importance Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα. Objective To assess the efficacy and safety of stapokibart as an add-on treatment to intranasal corticosteroids in patients…
This JAMA Insights explores topical treatments and systemic therapies for atopic dermatitis, the most common chronic inflammatory skin condition globally.
Importance With rapidly aging populations globally, there is a lack of evidence on effective fall prevention strategies among community-dwelling older people in resource-constrained areas. Objective To assess the effectiveness of a fall prevention program integrated in primary health care systems on the…
Importance Melanoma, the fifth most common cancer in the US, has increased from 8.8 per 100 000 in 1975 to 28.42 per 100 000 in 2022. Cutaneous melanoma comprises 94% of cases, with 104 960 US cases projected for 2025. Observations Cutaneous melanoma presents as…
A patient with a bioprosthetic aortic valve implanted 6 years prior to presentation had fevers, malaise, and weight loss. Coxiella burnetii titers, erythrocyte sedimentation rate, and levels of C-reactive protein and rheumatoid factor were elevated; transesophageal echocardiography showed a thickened…
This JAMA Insights discusses the most effective management strategies for tricuspid regurgitation, including medications and surgical interventions.
This JAMA Insights discusses medical consequences of and treatment options for methamphetamine use disorder, including harm reduction, behavioral treatment, and pharmacologic treatment.
Importance Hypothyroidism is a disease of thyroid hormone deficiency. The prevalence ranges from 0.3% to 12% worldwide, depending on iodine intake, and it is more common in women and older adults. Untreated hypothyroidism can cause serious health complications such as heart…
Importance When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of…
Screen use, the time spent engaging with electronic devices such as mobile phones and tablets, can become addictive when individuals experience difficulty stopping despite attempts to do so, as well as symptoms of withdrawal, tolerance, conflict, and relapse (Box). Adolescence…
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