Importance The permanent metallic occluders used for atrial septal defect (ASD) closure are associated with risks of late complications and may impede access to the left atrium. Bioresorbable occluders have the potential to address these limitations but have yet to be…
Importance Hyperglycemia-related pregnancy complications occur in 50% of pregnant women with type 1 diabetes. Closed-loop insulin systems improve glycemia outside of pregnancy but have had limited testing in pregnancy. Objective To assess the efficacy of a closed-loop system in pregnancy. Design, Setting,…
Importance Medicaid is the single largest source of health care coverage in the US, but health policy research on the Medicaid program has historically lagged research on Medicare due to limited availability of high-quality administrative claims data across states. In 2019,…
This case report discusses a patient with vertebral pseudoaneurysm that spontaneously ruptured and led to vertebro-vertebral arteriovenous fistula requiring endovascular therapy.
Importance Older adults represent the fastest-growing population initiating dialysis in the US. For older adults with advanced chronic kidney disease (CKD), initiating dialysis is often the default option presented, as they are often ineligible for kidney transplant. This approach may not…
This article illustrates the assumption of path symmetry in current theories of psychopathology and calls for the development of dynamical systems of mental illness that incorporate asymmetry.
A man in his 60s who had a kidney transplant was taking mycophenolate mofetil, tacrolimus, and prednisone presented with painless lesions on the left upper extremity. What is your diagnosis?
Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with day 90 all-cause mortality in patients with severe…
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
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