A woman in her 50s with type 2 diabetes presented with hyperpigmented plaques on her abdomen. Physical examination revealed symmetric, hyperkeratotic, verrucous plaques with thick, brownish, firmly adhered crusts. What is your diagnosis?
Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181],…
Importance The role of chemokine C-C motif ligand 5 (CCL5) in respiratory viral infections remains controversial; although essential for viral clearance, it is also implicated in pathogenic hyperinflammation. Objective To quantify associations between CCL5 levels and unfavorable disease progression and…
Importance Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a minimum weight loss of 5% in adults…
Importance Intravenous thrombolysis (IVT) is an established therapy for acute ischemic stroke when administered within 4.5 hours of symptom onset. However, many patients present beyond this window or with unknown onset, and recent randomized clinical trials (RCTs) have evaluated whether…
Importance Most diabetes care is managed in primary care settings, which represent a critical yet underutilized site for continuous glucose monitoring (CGM) adoption. Whether CGM initiation by primary care clinicians improves glycemic outcomes and reduces acute health care utilization remains…
Importance Metastatic prostate cancer (PC) incidence has increased in US men, partly due to changes in prostate-specific antigen (PSA) screening recommendations. However, few studies have examined contemporary PSA screening practices in large US health care systems. Objective To describe and…
Importance High-quality evidence guiding opioid prescribing decisions for acute pain across common diagnoses is lacking. Objective To describe pain trajectories and patterns of opioid and nonopioid treatment use among individuals who were offered opioids for the treatment of acute pain….
Importance Race, ethnicity, and social determinants of health (SDOH) contribute to disparities in diabetes outcomes, particularly hemoglobin A1c (HbA1c). Although continuous glucose monitoring (CGM) improves glycemic management, it remains unclear whether associations persist between SDOH and CGM metrics, as prior…
A 57-year-old man with bilateral red eyes and irritation refractory to topical corticosteroids presents with symmetric yellow conjunctival lesions and progressive systemic nodules and joint pain. What would you do next?
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