ECG Artifact Masking Complete Heart Block
This case report describes a woman in her 70s whose initial electrocardiogram (ECG) suggested ventricular tachycardia but presented asymptomatically to the emergency department.
ABMS Lifelong Learning CME Activity
Primary Aldosteronism
This Clinical Insights provides an overview of screening for and treating primary aldosteronism, including information on how medications may affect laboratory test results.
Designing Cardiovascular Outcomes Trials in Clonal Hematopoiesis of Indeterminate Potential
Importance Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as an independent and potent cardiovascular risk factor. As genetic sequencing becomes more widespread and the population ages, the identification of CHIP will increase substantially. Despite strong epidemiologic and mechanistic evidence…
Maternal RSVpreF Vaccine Effectiveness Against Respiratory Syncytial Virus in Hospitalized Infants
Importance In February 2025, Australia introduced maternal vaccination with bivalent respiratory syncytial virus prefusion F protein–based vaccine (RSVpreF) in the National Immunization Program for pregnant individuals from 28 weeks’ gestation as the primary, year-round strategy to prevent RSV disease in…
Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza, 2014-2023
Importance National organizations recommend antiviral treatment for hospitalized children with influenza; however, use in this setting has recently declined. Studies of oseltamivir effectiveness in children are limited by misclassification bias, unknown symptom onset date, and incomplete capture of antiviral use…
Diffuse Melanosis Cutis and Melanuria in Advanced Melanoma
This case report describes progressive slate-gray skin discoloration and darkening of urine and 2 primary cutaneous melanomas.
Family-Centered Child Obesity Treatment – The TEAM UP Randomized Clinical Trial
Importance Families have limited access to pediatric weight management services. Objective To compare the effectiveness of enhanced standard of care (ESOC) with family-based behavioral treatment (FBT) vs ESOC alone in reducing percent over median body mass index (percent median BMI)…
Clesrovimab in Infants at Increased Risk For Severe Disease During 2 RSV Seasons – A Randomized Clinical Trial
Importance Clesrovimab is a long-acting monoclonal antibody approved for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants who are born during or entering their first RSV season; data concerning clesrovimab from a second…
Atrial Pseudomasses in Erdheim-Chester Disease
This case report discusses a diagnosis of Erdheim-Chester disease in a patient in their early 70s who presented with chest pain, dyspnea, weight loss, and atrial pseudomasses on echocardiography.
Narcolepsy
This JAMA Insights discusses the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy.
