An Axillary Mass in Pulmonary Embolism
A 54-year-old woman presents with subacute exertional dyspnea after heavy lifting and a history of chronic repetitive upper-limb strain from caregiving. What would you do next?
ABMS Lifelong Learning CME Activity
Diagnosis and Treatment of Patients With Primary Aldosteronism
This JAMA Insights discusses various aspects of primary aldosteronism, such as its epidemiology, diagnosis and screening, and treatment, including effective medication management.
Hyperpigmented Plaques at Insulin Injection Sites
A woman in her 50s with type 2 diabetes presented with hyperpigmented plaques on her abdomen. Physical examination revealed symmetric, hyperkeratotic, verrucous plaques with thick, brownish, firmly adhered crusts. What is your diagnosis?
Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics
Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181],…
CCL5 Levels, Disease Progression, and Mortality in Respiratory Viral Infections – A Systematic Review and Meta-Analysis
Importance The role of chemokine C-C motif ligand 5 (CCL5) in respiratory viral infections remains controversial; although essential for viral clearance, it is also implicated in pathogenic hyperinflammation. Objective To quantify associations between CCL5 levels and unfavorable disease progression and…
A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity – The PRAMEV Randomized Clinical Trial
Importance Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a minimum weight loss of 5% in adults…
Intravenous Thrombolysis Beyond the Conventional Time Window for Acute Ischemic Stroke – A Systematic Review and Meta-Analysis
Importance Intravenous thrombolysis (IVT) is an established therapy for acute ischemic stroke when administered within 4.5 hours of symptom onset. However, many patients present beyond this window or with unknown onset, and recent randomized clinical trials (RCTs) have evaluated whether…
Primary CareInitiated Continuous Glucose Monitoring in Adults With Insulin-Treated Diabetes
Importance Most diabetes care is managed in primary care settings, which represent a critical yet underutilized site for continuous glucose monitoring (CGM) adoption. Whether CGM initiation by primary care clinicians improves glycemic outcomes and reduces acute health care utilization remains…
Prostate-Specific Antigen Screening Patterns and Metastatic Prostate Cancer in US Veterans
Importance Metastatic prostate cancer (PC) incidence has increased in US men, partly due to changes in prostate-specific antigen (PSA) screening recommendations. However, few studies have examined contemporary PSA screening practices in large US health care systems. Objective To describe and…
Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients
Importance High-quality evidence guiding opioid prescribing decisions for acute pain across common diagnoses is lacking. Objective To describe pain trajectories and patterns of opioid and nonopioid treatment use among individuals who were offered opioids for the treatment of acute pain….
