Diffuse Melanosis Cutis and Melanuria in Advanced Melanoma
This case report describes progressive slate-gray skin discoloration and darkening of urine and 2 primary cutaneous melanomas.
ABMS Lifelong Learning CME Activity
Family-Centered Child Obesity Treatment – The TEAM UP Randomized Clinical Trial
Importance Families have limited access to pediatric weight management services. Objective To compare the effectiveness of enhanced standard of care (ESOC) with family-based behavioral treatment (FBT) vs ESOC alone in reducing percent over median body mass index (percent median BMI)…
Clesrovimab in Infants at Increased Risk For Severe Disease During 2 RSV Seasons – A Randomized Clinical Trial
Importance Clesrovimab is a long-acting monoclonal antibody approved for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants who are born during or entering their first RSV season; data concerning clesrovimab from a second…
Atrial Pseudomasses in Erdheim-Chester Disease
This case report discusses a diagnosis of Erdheim-Chester disease in a patient in their early 70s who presented with chest pain, dyspnea, weight loss, and atrial pseudomasses on echocardiography.
Narcolepsy
This JAMA Insights discusses the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy.
Rheumatoid Arthritis in Adults – A Review
Importance Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and destruction of cartilage and adjacent bone and can lead to irreversible disability. Rheumatoid arthritis affects 0.53% of adults worldwide and 0.74% of US adults. Observations Rheumatoid arthritis…
Evidence for Social Media Legislation Strategies
Importance Social media use has grown rapidly, with particularly high adoption among adolescents. These patterns carry both risks, such as problematic use, and potential benefits, such as social connection, creating challenges for policymakers developing regulatory approaches. Objective To synthesize existing…
Uveal Hypopigmentation Revealing Waardenburg Syndrome
This case report discusses a clinical diagnosis of Waardenburg syndrome type II in a woman aged 69 years who presented with bilateral iris and choroidal hypopigmentation and hyperpigmentation and a history of congenital deafness, iris heterochromia, and a gray hair…
Management of Soft Tissue and Visceral Leiomyosarcomas
Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize management and address remaining clinical and…
Why Metrics Matter in Thyroid Eye Disease – An Innovate TED Initiative
Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the…
