Importance Cardiovascular inflammation is a major determinant of atherosclerotic disease, and inhibition of the central signaling cytokine, interleukin 6 (IL-6), is a promising target for intervention. Patients with chronic kidney disease (CKD) commonly have plasma elevations of inflammatory biomarkers, such as…
Importance Neuropsychiatric disorders impose a substantial burden on individuals and societies worldwide. Despite significant advances in the understanding of the brain, only a handful of mechanism-based treatments for psychiatric disorders have been discovered and validated in the past 50 years. Observations After…
Importance Compounded with barriers to care, stigmatization, lack of trust, and high rates of psychiatric comorbidities, transmasculine patients face a high psychosocial burden from acne. Acne is a common sequela of masculinizing hormone therapy, and understanding its epidemiology may improve care…
A previously healthy man had headache, chest pain, abdominal pain, vomiting, and diarrhea 1 hour after eating raw tuna sashimi. His blood pressure was 67/42 mm Hg, and he had an erythematous nonpruritic rash on his upper torso, ST-segment elevation…
This case report describes a man in his 50s with broad-spectrum abnormal localized photosensitivity syndrome.
This case report discusses a diagnosis of epiretinal hyperproliferative complex in a male patient aged 75 years with a history of multiple myeloma who reported blurred vision in his left eye persisting after cataract surgery.
A 61-year-old man presented to the otolaryngology clinic with a 2-month history of progressive hoarseness, dysphagia, odynophagia, and persistent globus sensation. What is your diagnosis?
Importance Head and neck cancer, which arises in the lining or mucosa of the upper aerodigestive tract, specifically the oral cavity, oropharynx, larynx, hypopharynx, and paranasal sinuses, is the seventh most common cancer worldwide. In 2024, approximately 71 110 individuals in the…
Importance Primary care provides a broad service range, including preventive screenings and chronic disease care. Busy clinicians frequently select which health care processes to address per visit based on time or perceived disease impact, especially for patients with multimorbidity. Little evidence…
Importance Primary mitral regurgitation (MR) is a prevalent valvular lesion. Current American College of Cardiology/American Heart Association guidelines include class I recommendations for intervention for severe primary MR at the onset of symptoms, significant left ventricular (LV) enlargement (end-systolic dimension ≥40…
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