Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective To establish consensus-based morphological definitions of HS lesions and guidance…
This case report describes a woman in her 30s with porcelain-white discoloration of all nails, which persisted under pressure, and a GJA1 mutation.
This activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast about key ideas from disability ethics that can inform our thinking about age-related biases and how medicalizing aging affects our health,…
Advances in epigenetic age estimation are now applied in actuarial science to make risk assessment more precise. But such health insurance underwriting practices pose ethical and legal questions about discrimination, privacy, and equity in biological data use. Legal adaptations, such…
Documenting one’s assessment of a patient’s physical appearance during a clinical encounter is regarded as a key element in a clinician’s overall judgment of a patient’s health. This article considers ethically and clinically relevant uses and misuses of such appraisals…
This commentary on a case considers how clinicians should help patients interpret results of tests that might be personally meaningful but not clinically actionable. Tests of biological age, for example, can easily lead to patient misunderstandings that can increase risks…
Importance Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and economic burden. Glucagon-like peptide-1 therapies (GLP-1 therapies) provide clinically meaningful weight loss and broad metabolic benefits. In response to Member State requests, the…
Importance Pertussis, or whooping cough, is caused by the Bordetella pertussis bacterium. It induces prolonged cough in all age groups and is a severe, life-threatening disease in young infants. Observations In an online workshop organized by the International Bordetella Society on November 12, 2024,…
Importance The prevalence of high blood pressure in children is increasing, with health consequences reaching into adulthood. Individual-level interventions may help address the burden of high blood pressure at a population level, but there is less evidence from pediatric settings. Objective To…
This case report describes a unique presentation of Kelch-like protein 11 antibody-associated paraneoplastic encephalitis in an 81-year-old woman with a high-grade neuroendocrine carcinoma consistent with metastatic Merkel cell carcinoma.
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