Journal-based

China’s Social Health Insurance in the Era of Rapid Population Aging

Importance  This Special Communication addresses one of the most pressing health policy issues: the impact of population aging on the sustainability of social health insurance systems. It presents a comprehensive review of China’s achievements as of 2024 in improving social health…

SPIRIT 2025 Statement – Updated Guideline for Protocols of Randomized Trials

Importance  The protocol of a randomized trial is the foundation for study planning, conduct, reporting, and external review. However, trial protocols vary in their completeness and often do not address key elements of design and conduct. The SPIRIT (Standard Protocol Items:…

Non–Cystic Fibrosis Bronchiectasis in Adults A Review

Importance  Non–cystic fibrosis (CF) bronchiectasis is a chronic lung condition caused by permanent bronchial dilatation and inflammation and is characterized by daily cough, sputum, and recurrent exacerbations. Approximately 500 000 people in the US have non-CF bronchiectasis. Observations  Non-CF bronchiectasis may be associated…

Factor V Leiden

This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.

An Isolated Red Plaque on the Anterior Chest

A 6-year-old girl had a slightly sunken red plaque that was observed on the chest, approximately 1.5 cm in diameter, with a smooth surface, associated vascular dilation, well-defined borders, and no scaling or ulceration. What is your diagnosis?

Melanoma-Associated Leukoderma

This case report describes a woman with color change involving only the facial skin and was later found to also have inguinal lymph node and rectal mass.

Management of Adult Acute Lymphoblastic Leukemia – A Review

Importance  Research in acute lymphoblastic leukemia (ALL) is translating into rapid changes in therapy and outcomes. Historically, adult ALL was treated with intensive chemotherapy extending over 2.5 to 3 years. This established tradition, accepted because of the high cure rates in…