An Anal Lesion in a 27-Year-Old Patient
A 27-year-old male patient presented with anal discomfort and pruritus for 3 months. What is your diagnosis?
JAMA Oncology
Externally Controlled Studies Using Real-World Data in Patients With Hematological Cancers – A Systematic Review
Importance The use of real-world data (RWD) external control arms in prospective studies is increasing. The advantages, including the immediate availability of a control population, must be balanced with the requirements of meeting evidentiary standards. Objective To address the question of whether…
Heterogeneity of Residual Disease After Neoadjuvant Systemic Therapy in Breast Cancer – A Review
Importance Over the past 2 decades, systemic therapy for early-stage breast cancer has gradually moved from the adjuvant to the neoadjuvant setting. Administration of systemic therapy before surgery leads to potential improvements in surgical outcomes and allows for the assessment of…
Recurrent Fevers in a Patient With Splenomegaly
A 36-year-old man presented with 10 weeks of recurrent fevers, malaise, night sweats, unintentional weight loss, and dyspnea. What is your diagnosis?
A Case of Gastric Thickening and a Large Ovarian Mass
A 35-year-old female patient with hypothyroidism and Ehler-Danlos syndrome presents with fatigue, abdominal distension, and dyspnea. What is your diagnosis?
Lymphoma With a Skin Rash
A 62-year-old female had a generalized vesiculobullous rash on her face for 4 months. It started over the lips and gradually progressed to involve the oral mucosa and skin of the whole body. What is your diagnosis?
Current Management of Desmoid Tumors – A Review
Importance Desmoid tumor (DT) is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Previously, surgery was the standard primary treatment modality; however, within the past decade, a paradigm shift toward less-invasive management…
Obstacles to Biosimilar Acceptance and Uptake in Oncology – A Review
Importance Biosimilar drugs provide cost-effective yet clinically indistinguishable replications of target drugs. During initial development, this class of biologic medicines was expected to revolutionize pharmaceutical markets; however, following US Food and Drug Administration approval of the first biosimilar drug in 2015,…
Metastatic Hormone-Sensitive Prostate Cancer and Combination Treatment Outcomes – A Review
Importance Metastatic hormone-sensitive prostate cancer is currently an incurable disease. Despite a high response rate to androgen-deprivation therapy, most cases progress to castration-resistant disease, the terminal phase. This review provides a summary of the most recent evidence for current and emerging…
Immune Checkpoint Inhibitor Therapy Before Nephrectomy for Locally Advanced and Metastatic Renal Cell Carcinoma – A Review
Importance The therapeutic landscape of advanced renal cell carcinoma (RCC) has rapidly evolved in the past 2 decades, with the advent of cytokines therapy followed by targeted therapies and novel immune checkpoint inhibitors (ICI). This article aims to review the current…
