A Patient With Prior Skin Cancers and New Diagnosis of Bell Palsy
A 78-year-old man with a history of nonmelanoma skin cancers presented with left-sided upper and lower facial weakness. What is your diagnosis?
JAMA Oncology
Childhood Cancer Survivorship Globally – A Systematic Review
Importance As childhood cancer survival improves worldwide, supporting the growing survivor population, who are at increased risk of morbidity and mortality compared with the general population, is critical. No prior publications have summarized the landscape of childhood cancer survivorship research globally…
Current Controversies and Challenges in Non–Oncogene-Addicted Synchronous Oligometastatic Non–Small Cell Lung Cancer – A Review
Importance It has been stated that especially with the advancements in imaging, systemic therapy, and local radical treatment (LRT) that patients with synchronous oligometastatic disease (sOMD) can potentially benefit from curative-intent treatment. This statement is challenged by the results of the…
Emerging EGFR-Targeted Therapy in Head and Neck Cancer – A Review
Importance Head and neck squamous cell carcinoma (HNSCC) represents a significant global health burden with limited therapeutic options for patients with recurrent or metastatic disease. Epidermal growth factor receptor (EGFR) is overexpressed in most patients with HNSCC and represents a biologically…
Prognostic and Predictive Insights From Genomic Assays for Breast Cancer in Diverse Populations – A Review
Importance Despite recent declines in breast cancer mortality rates, substantial disparities persist among race and ethnicity groups. Genomic assays are crucial for understanding the biological characteristics of tumors, providing valuable insights into prognosis and treatment response. Their integration into personalized clinical…
Management of Adult Acute Lymphoblastic Leukemia – A Review
Importance Research in acute lymphoblastic leukemia (ALL) is translating into rapid changes in therapy and outcomes. Historically, adult ALL was treated with intensive chemotherapy extending over 2.5 to 3 years. This established tradition, accepted because of the high cure rates in…
Autoamputation in Mismatch Repair–Deficient Colon Cancer
A woman in her 50s with a history of hemochromatosis, psoriasis, and type 2 diabetes presented with a 3-month history of abdominal pain, weight loss, and a large palpable fixed abdominal mass. What is your diagnosis?
Foot Lesions and Perianal Lump in an Adult Woman
A 50-year-old woman presented to the dermatology department with a 10-year history of recurrent plaque outbreaks between her toes and a history of Bowen disease in the anus that had been treated with excision and skin grafting. What is your…
Tongue Lesions While Undergoing Cancer Therapy
A woman in her 40s with well-differentiated neuroendocrine tumor of the pancreas with liver metastases undergoing treatment with oral cabozantinib presented to a routine oncology appointment with tongue lesions for 1 week. What is your diagnosis?
Biomarker-Directed Radiotherapy in Breast Cancer – A Narrative Review
Importance Integration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk…
