Importance Intravenous thrombolysis (IVT) is an established therapy for acute ischemic stroke when administered within 4.5 hours of symptom onset. However, many patients present beyond this window or with unknown onset, and recent randomized clinical trials (RCTs) have evaluated whether…
Importance Most diabetes care is managed in primary care settings, which represent a critical yet underutilized site for continuous glucose monitoring (CGM) adoption. Whether CGM initiation by primary care clinicians improves glycemic outcomes and reduces acute health care utilization remains…
Importance Metastatic prostate cancer (PC) incidence has increased in US men, partly due to changes in prostate-specific antigen (PSA) screening recommendations. However, few studies have examined contemporary PSA screening practices in large US health care systems. Objective To describe and…
Importance High-quality evidence guiding opioid prescribing decisions for acute pain across common diagnoses is lacking. Objective To describe pain trajectories and patterns of opioid and nonopioid treatment use among individuals who were offered opioids for the treatment of acute pain….
Importance Race, ethnicity, and social determinants of health (SDOH) contribute to disparities in diabetes outcomes, particularly hemoglobin A1c (HbA1c). Although continuous glucose monitoring (CGM) improves glycemic management, it remains unclear whether associations persist between SDOH and CGM metrics, as prior…
The US Centers for Disease Control and Prevention (CDC) define health equity as “the state in which everyone has a fair and just opportunity to attain their highest level of health.” Achieving this, according to the CDC, requires sustained efforts…
Importance Due to the impact of high-potency synthetic opioids on medication for opioid use disorder (MOUD) initiation, hospital-based addiction clinicians adapted their practice to improve care, with decisions often guided by limited evidence. Objective To derive expert consensus on best…
Importance Children in the US are disproportionately affected by disasters. However, pediatric-specific disaster medicine research remains limited, underscoring an urgent need for a pediatric-focused disaster medicine research agenda for the US to improve outcomes and preparedness for future events. Objective …
Importance Surgical quality assessment has largely focused on addressing risk-adjusted postoperative outcomes, which neglects quality assessment across the entire perioperative surgical continuum. The Veterans Health Administration (VA) has the unique opportunity to employ a surgical episode framework to measure surgical…
Importance Women experiencing more severe menopausal symptoms exhibit poorer quality of life, and those with early menopause have a higher risk of developing chronic diseases. However, the extent to which neighborhood disadvantage contributes to menopause onset and symptom severity remains…
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