Importance Gestational diabetes is associated with future cardiometabolic risk, but postpartum evidence across the cardiovascular-kidney-metabolic (CKM) disorder spectrum remains limited. Objective To characterize the timing and magnitude of incident postpartum CKM disorders after a pregnancy complicated by gestational diabetes. Design,…
Importance Genetic ancestry may complement biological, behavioral, and clinical factors in understanding colorectal cancer (CRC) disparities; yet, ancestry-informed analyses in CRC remain limited. Objective To characterize associations of genetic ancestry with CRC burden, age at diagnosis, and age-specific risk, and…
This nonrandomized clinical trial assesses the safety and efficacy of darolutamide, with or without concomitant lipid-modifying agents (LMAs), in treating nonmetastatic castration-resistant prostate cancer.
Importance Patients with breast cancer (BC) may have long-term fatigue after treatment, which is associated with reduced quality of life. Objective To identify cardiac, psychological, and cancer treatment factors associated with fatigue before and 24 months after BC treatment. Design,…
Importance Smoking is the strongest modifiable risk factor for peripheral arterial disease (PAD), yet evidence on how postdiagnosis smoking behavior changes affect clinical outcomes remains limited. Objective To evaluate the association among smoking cessation, reduction, and continuation after PAD diagnosis…
Importance Black women are disproportionately susceptible to developing heart failure and display more severe morbidity and mortality compared with White women. Factors contributing to excess heart failure risk among Black women remain incompletely understood. Objective To characterize the associations of…
Importance Evidence on the association of excess adiposity with colorectal cancer (CRC) prognosis is conflicting, with some studies reporting better survival in patients with elevated body mass index (BMI)—often referred to as the obesity paradox. Objective To investigate to what…
Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181],…
Importance The role of chemokine C-C motif ligand 5 (CCL5) in respiratory viral infections remains controversial; although essential for viral clearance, it is also implicated in pathogenic hyperinflammation. Objective To quantify associations between CCL5 levels and unfavorable disease progression and…
Importance Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a minimum weight loss of 5% in adults…
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