JAMA Network Open

Prevalence of Central Sensitization in Postural Tachycardia Syndrome

Importance  A previous study showed a high prevalence of central sensitization syndrome (CSS) in patients with autonomic symptoms. The prevalence of CSS in postural tachycardia syndrome (POTS), a form of dysautonomia, is unknown. Objectives  To analyze the prevalence of CSS…

Opportunistic Genomic Screening for Familial Hypercholesterolemia to Improve Low-Density Lipoprotein Cholesterol – A Randomized Clinical Trial

Importance  The clinical benefit of opportunistic genomic screening for familial hypercholesterolemia (FH) has not been demonstrated in a randomized clinical trial (RCT). Objective  To evaluate the impact of returning clinically confirmed FH-associated genetic results on low-density lipoprotein cholesterol (LDL-C) levels….

Metformin, Maternal Glycemic Control, and Neonatal Hypoglycemia After Antenatal Steroids – A Randomized Clinical Trial

Importance  Although betamethasone reduces complications of prematurity, it can cause maternal hyperglycemia and neonatal hypoglycemia. Metformin effectively treats maternal hyperglycemia and has been shown to decrease neonatal hypoglycemia in women with gestational diabetes. Objective  To evaluate the impact of metformin…

Perceptions of GLP-1 RA Use for Children With Obesity Among Caregivers With Food Insecurity – A Qualitative Study

Importance  With the approval of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for pediatric obesity, families are increasingly considering pharmaceutical treatment alongside lifestyle optimization for their children, although how caregivers will make these decisions remains unexplored. This is especially important in…