An Axillary Mass in Pulmonary Embolism
A 54-year-old woman presents with subacute exertional dyspnea after heavy lifting and a history of chronic repetitive upper-limb strain from caregiving. What would you do next?
JAMA Cardiology
Right Atrial Ectopic Hepatic Tissue at the Caval Inflow
This case report discusses a finding of ectopic hepatic tissue near the inferior vena cava orifice found on incidental examination of a 31-year-old pregnant woman.
Premature Menopause and Lifetime Risk of Coronary Heart Disease
Importance Premature onset of menopause is associated with increased short-term risk of coronary heart disease (CHD), but the associated long-term CHD risk and whether this differs by self-identified race are not known. Objective To calculate lifetime risk estimates of incident…
A Contemporary Look at the Landscape of Treatment of Tricuspid Regurgitation – A Review
Importance Untreated severe tricuspid regurgitation carries a poor prognosis. We aim to provide a contemporary review of the anatomy, clinical manifestations, and diagnostic and management strategies, including medical, surgical and transcatheter options. By synthesizing current knowledge, this review seeks to equip…
Rationale, Design, and Baseline Clinical Characteristics of the Ziltivekimab Cardiovascular Outcomes Trial
Importance Cardiovascular inflammation is a major determinant of atherosclerotic disease, and inhibition of the central signaling cytokine, interleukin 6 (IL-6), is a promising target for intervention. Patients with chronic kidney disease (CKD) commonly have plasma elevations of inflammatory biomarkers, such as…
Myocardial Dysfunction in Primary Mitral Regurgitation – A Review
Importance Primary mitral regurgitation (MR) is a prevalent valvular lesion. Current American College of Cardiology/American Heart Association guidelines include class I recommendations for intervention for severe primary MR at the onset of symptoms, significant left ventricular (LV) enlargement (end-systolic dimension ≥40…
Exertional Syncope in a Female Teenage Student
A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR, and laboratory results indicated elevated cardiac troponin T levels. What would you do next?
Chest Pain and Chest Wall Deformity
A man in his mid-30s with a history of Crohn disease presented with several years of intermittent, nonexertional chest pressure. What would you do next?
Approach to the Postmarket Evaluation of Consumer Wearable Technologies
Importance Consumer wearable technologies have wide applications, including some that have US Food and Drug Administration clearance for health-related notifications. While wearable technologies may have premarket testing, validation, and safety evaluation as part of a regulatory authorization process, information on their…
Asymptomatic Grade 6 Diastolic Murmur in an Adult
A previously healthy 55-year-old man presented to his local family medicine clinic after waking up with a buzzing sensation in his chest. What would you do next?
