JAMA Cardiology

Left Ventricular Noncompaction Cardiomyopathy

This case report describes an echocardiography-based diagnosis of left ventricular noncompaction cardiomyopathy in a male patient in his 40s who presented with sudden-onset dyspnea.

Patent Foramen Ovale and Dysarthria in a Man in His 60s

This case report describes a diagnosis of patent foramen ovale in a man in his 60s presenting with stroke symptoms and multifocal infarcts on magnetic resonance imaging of the brain.

Preserving and Promoting Clinical Trial Representativeness – A Review of Existing Strategies and the Path Forward

Importance  Despite major advancements in cardiovascular clinical research, underrepresentation in cardiovascular clinical trials persists, limiting generalizability, access to novel therapies, and equitable care. Observations  Policymakers, funding bodies, researchers, and professional societies have increasingly acknowledged the scientific importance of representation of the intended…

Recurrent Chest Pain in a Young Female Patient With Family History of Cancer

A female patient presents with chest pain, and echocardiography reveals moderate circumferential pericardial effusion, leading to a diagnosis of acute pericarditis. Initial cardiac magnetic resonance imaging phase-sensitive inversion recovery sequences in the sagittal section depict late gadolinium enhancement on the…

Recognition of the Large Ambulatory C2D Stage of Advanced Heart Failure—A Call to Action

Importance  The advanced ambulatory heart failure (HF) population comprises patients who have progressed beyond the pillars of recommended stage C HF therapies but can still find meaningful life-years ahead. Although these patients are commonly encountered in practice, national databases selectively capture…

Coronary Artery Calcium Testing—Too Early, Too Late, Too Often

Importance  Traditional risk factors, enhancing factors, and risk scores help clinicians assess atherosclerotic cardiovascular disease (ASCVD) risk for primary prevention. The latest cholesterol guidelines suggest measuring coronary artery calcium (CAC) score by computed tomography (CT) in those at intermediate risk when…