JAMA Cardiology

Interventions for Optimization of Guideline-Directed Medical Therapy – A Systematic Review

Importance  Implementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF). Objective  To perform a systematic review…

Transient Monocular Blindness in a Man in His 30s

This case report discusses a diagnosis of giant ascending aortic aneurysm in a patient who presented with transient monocular blindness and no cardiovascular symptoms.

A Female Patient With Recurrent Headache and Syncope

This case report discusses a diagnosis of pulmonary arteriovenous fistulas in a female patient in her 30s who presented with a 5-year history of hypoxia, syncope, and headaches.

Adenosine Triphosphate Citrate Lyase and Fatty Acid Synthesis Inhibition – A Narrative Review

Importance  Adenosine triphosphate citrate lyase (ACLY) is a key regulatory enzyme of glucose metabolism, cholesterol and fatty acid synthesis, and the inflammatory cascade. Bempedoic acid, an ACLY inhibitor, significantly reduces atherogenic lipid markers, including low-density lipoprotein cholesterol (LDL-C), non–high-density lipoprotein cholesterol,…

An Elderly Woman With Ventricular Tachycardia

A woman in her 90s presented to the emergency department with fever, hemoptysis, and syncopal episodes. An electrocardiogram showed monomorphic ventricular tachycardia with a morphology suggesting right ventricular (RV) origin. What would you do next?

Deep Learning for Cardiovascular Imaging – A Review

Importance  Artificial intelligence (AI), driven by advances in deep learning (DL), has the potential to reshape the field of cardiovascular imaging (CVI). While DL for CVI is still in its infancy, research is accelerating to aid in the acquisition, processing, and/or…