Importance Pituitary adenomas are neoplasms of the pituitary adenohypophyseal cell lineage and include functioning tumors, characterized by the secretion of pituitary hormones, and nonfunctioning tumors. Clinically evident pituitary adenomas occur in approximately 1 in 1100 persons. Observations Pituitary adenomas are classified as…
Importance The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. Objective To determine whether vitamin C improves outcomes for patients with COVID-19. Design, Setting, and Participants Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in…
An older patient with stage II bladder carcinoma presented with 1 week of fatigue and 2 days of dyspnea on exertion. He was receiving carboplatin/gemcitabine with 6 mg of pegylated G-CSF chemotherapy; his white blood cell count was elevated, hemoglobin…
This JAMA Guide to Statistics and Methods explains the use of historical controls persons who had received a specific control treatment in a previous study when randomizing participants to that control treatment in a subsequent trial may not be practical…
This JAMA Insights in the Women’s Health series discusses diagnosis of uterine prolapse and available surgical and nonsurgical treatment options.
This JAMA Insights discusses the use of antibiotics for sexually transmitted infection prevention.
This JAMA Insights in the Women’s Health series describes the use of fezolinetant and neurokinin B antagonists as nonhormonal therapies for menopausal vasomotor symptoms.
This JAMA Insights reviews the complex driving needs of older individuals and how clinicians can help address these needs, including recommending use of supplemental technology, assessing fitness to drive, and reviewing medications that may impair driving ability.
A patient who had recently undergone bilateral mastectomy had erythema, edema, pain, pruritus, serous fluid drainage at the incision sites, and an erythematous papulovesicular rash on the trunk and extremities. A skin swab bacterial culture result was negative, and the…
A 10-year-old girl with spina bifida and neurogenic bowel hospitalized for abdominal pain, dehydration, and more than 20 episodes of diarrhea per day. A stool sample test result was positive for Clostridioides difficile by polymerase chain reaction and an enzyme…
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