Medical Knowledge

Interventions for Proliferative Vitreoretinopathy

Clinical Question  What is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy? Bottom Line  There is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.

Prognostic Value of Cardiovascular Biomarkers in the Population

Importance  Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. Objective  To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Design, Setting, and Participants  Individual-level…

Uterine Tachysystole, Part 2: Reducing Diagnosis-to-Treatment Time

One in three pregnant patients run the risk of experiencing uterine tachysystole (UT) during labor augmentation or induction with oxytocin. Reducing UT diagnosis-to-treatment time can avert adverse patient outcomes and decrease the risk of an obstetric malpractice claim. This two-part…

Uterine Tachysystole, Part 1: Guidelines & Identification

One in three pregnant patients run the risk of experiencing uterine tachysystole (UT) during labor augmentation or induction with oxytocin. Reducing UT diagnosis-to-treatment time can avert adverse patient outcomes and decrease the risk of an obstetric malpractice claim. This two-part…

Diagnostic Safety, Part 2: Impediments to Diagnostic Reasoning

Researchers have identified more than 100 biases that can interfere with diagnostic reasoning. These biases can sway practitioners’ thinking during both intuitive and deliberative cognitive processes. This activity discusses biases and offers strategies to reduce their detrimental impacts.

OP Malpresentation: A Precarious Situation

Fetal malpresentation is defined as a fetus presenting at birth in a non-vertex presentation as either occiput transverse (OT) or occiput posterior (OP). This condition occurs 15% to 25% at term and 5% to 12% at birth, frequently increases risk…

Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement – A Randomized Clinical Trial

Importance  Most people who smoke do not quit on their initial attempt. Objective  To determine the best subsequent strategy for nonabstinence following initial treatment with varenicline or combined nicotine replacement therapy (CNRT). Design, Setting, and Participants  Using a double-blind, placebo-controlled, sequential multiple assignment…

A Brief History of Antimicrobial Resistance

Despite mounting attention in recent years, health threats posed by antimicrobial resistance are not new. Antimicrobial resistance has dogged infectious disease treatment processes since the first modern antimicrobials were discovered.

Management of Gallstone Pancreatitis – A Review

Importance  Gallstone pancreatitis (GSP) is the leading cause of acute pancreatitis, accounting for approximately 50% of cases. Without appropriate and timely treatment, patients are at increased risk of disease progression and recurrence. While there is increasing consensus among guidelines for the…