Medical Knowledge

Second Primary Cancer After Chimeric Antigen Receptor–T-Cell Therapy – A Review

Importance  The commercialization of chimeric antigen receptor–T-cell (CAR-T) therapy has changed the landscape of treatment of hematological cancers. Numerous studies from the early 2000s paved the way for cell-based targeted therapeutics, which have been established as practice-changing therapies in lymphoma, leukemia,…

Atrial Fibrillation – A Review

Importance  In the US, approximately 10.55 million adults have atrial fibrillation (AF). AF is associated with significantly increased risk of stroke, heart failure, myocardial infarction, dementia, chronic kidney disease, and mortality. Observations  Symptoms of AF include palpitations, dyspnea, chest pain, presyncope, exertional…

What Should Health Professions Students Learn About Data Bias?

In epidemiology, bias is defined as systematic deviation from the truth, and it can arise at different stages of scientific investigation (eg, data collection, methodological application, and outcomes analysis). Epidemiological bias can appear as a consequence of data bias (usually…

How Should Epidemiologists Respond to Data Genocide?

Data quality for and about American Indian/Alaska Native (AI/AN) people is undermined by deeply entrenched, colonial practices that have become standard in US federal data systems. This article draws on cases of maternal mortality and COVID-19 to demonstrate the ethical…

All About Cannabis Pharmacology

Pain expert Samer Narouze, MD, PhD talks about the pharmacology of cannabis, including the chemical structures, mechanism of action in the body, and pharmacodynamics of cannabinoids. This episode also addresses clinical information related to potential drug-drug interactions and adverse events…

Ethics Talk: Underrecognized Origins of Epidemiology

This activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast about therapeutic music and peace in health care. The featured guests are James Downs, PhD, the Gilder Lehrman-National Endowment for the…

2024 Ethics Symposium: Harm Reduction and Opioid Use Disorder

The AMA Journal of Ethics presents the 2024 Ethics Symposium: Harm Reduction and Opioid Use Disorder. Two speakers today share their insights on state of the art in clinical, public health, and forensic approaches to harm reduction. Speakers are Dr…