Subglottic Mass With Hoarseness and Difficulty Breathing
A man in his 70s was referred for a 5-cm submandibular mass, hoarseness, and difficulty breathing with no cough, blood in sputum, or dysphagia. What is your diagnosis?
Medical Knowledge
Chloracne
This case report describes hyperpigmented, pruritic lesions on the patient’s face and chest that worsened over the previous 3 weeks.
Distinct Magnetic Resonance Imaging in a Child With a TACO1 Variant
This case report describes a unique magnetic resonance imaging result in a young boy with a TACO1 variant.
Lateral Neck Bulging and Pain on Swallowing in a Young Man
A 28-year-old man presents with a bulge on the left side of his neck and severe stabbing pain during swallowing. He had a history of a neck contusion 1 year prior with subcutaneous bleeding that had improved. What is your…
Retiform Ulceration and Bullae on the Bilateral Thighs
A man with a history of polysubstance use presents with new bullae on his bilateral lower extremities. What is your diagnosis?
Updates in Primary Immunodeficiency 2025
Early diagnosis and appropriate management are crucial for improving the quality of life and prognosis for those with IEI. Advances in genetic research and therapies continue to improve outcomes for many patients with these disorders. However, IEI can be challenging…
A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain
A 3-year-old had spontaneous gingival hemorrhage and bilateral limb weakness with inability to bear weight. He had no preceding oral trauma or recent infection, took no regular medications, and had no recent use of aspirin or nonsteroidal anti-inflammatory drugs; his…
Opioid-Induced Adrenal Insufficiency
This case report describes a woman in her 40s with opioid use disorder receiving methadone who was admitted for extended antibiotic treatment for methicillin-resistant Staphylococcus aureus bacteremia and was subsequently diagnosed with opioid-induced adrenal insufficiency.
Acute Corneal Edema in a Middle-Aged Patient
A middle-aged patient who had bilateral penetrating keratoplasty 20 years ago for keratoconus presented with pain and blurriness of the right eye for 2 days. Despite prompt corticosteroid therapy, they had no vision improvement and reported occasional pain. What would…
Climate Change and Mental Health
This JAMA Insights discusses the adverse effects of climate change on mental health and proposes solutions to help mitigate those effects.
