Vitamin D for Prevention of Disease
This JAMA Clinical Guidelines Synopsis summarizes the Endocrine Society’s most recent recommendations on vitamin D supplementation for disease prevention.
Medical Knowledge
Varenicline for Youth Nicotine Vaping Cessation – A Randomized Clinical Trial
Importance Electronic cigarette use (vaping) among adolescents and young adults is common. Few treatments have been tested in this population. Objective To evaluate the efficacy of varenicline for nicotine vaping cessation in youth who do not smoke tobacco regularly. Design, Setting, and…
Cuffless Blood Pressure Measurement Devices—International Perspectives on Accuracy and Clinical Use A Narrative Review
Importance Hypertension is a primary modifiable risk factor for cardiovascular death and disability. Accurate blood pressure (BP) measurement is essential for the diagnosis and treatment of hypertension. Conventional BP measurement with cuff devices is recommended but difficult for patients to perform…
Epistaxis and a Large Nasal Mass in an Adolescent Male
A 16-year-old male with a history of mild seasonal allergies presented with right-sided congestion, thick discolored nasal drainage, facial pain/pressure, anosmia, and intermittent epistaxis for approximately 1 year. What is your diagnosis?
Lipoprotein(a)
This JAMA Insights discusses lipoprotein(a), including factors associated with elevated lipoprotein(a) levels, how to manage them, and atherosclerotic cardiovascular disease risk.
Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US
Importance Widespread childhood vaccination has eliminated many infectious diseases in the US. However, vaccination rates are declining, and there are ongoing policy debates to reduce the childhood vaccine schedule, which may risk reemergence of previously eliminated infectious diseases. Objective To estimate the…
Neoadjuvant Therapy for Mucosal Head and Neck Squamous Cell Carcinoma A Review From the American Head and Neck Society
Importance While neoadjuvant chemotherapy for head and neck squamous cell carcinoma dates to the earliest multidisciplinary approaches, the introduction of immune checkpoint inhibitors (ICIs) has renewed enthusiasm and research into its use. Although neoadjuvant therapy has remained mostly investigative through single-institutional…
Trends in Mental Health Diagnoses Among Publicly Insured Children
Importance Children living in poverty are at increased risk of mental health and neurodevelopmental disorders. Little is known about the trends in diagnoses of these disorders among children enrolled in public insurance programs, such as Medicaid, which insure more than 1…
China’s Social Health Insurance in the Era of Rapid Population Aging
Importance This Special Communication addresses one of the most pressing health policy issues: the impact of population aging on the sustainability of social health insurance systems. It presents a comprehensive review of China’s achievements as of 2024 in improving social health…
SPIRIT 2025 Statement – Updated Guideline for Protocols of Randomized Trials
Importance The protocol of a randomized trial is the foundation for study planning, conduct, reporting, and external review. However, trial protocols vary in their completeness and often do not address key elements of design and conduct. The SPIRIT (Standard Protocol Items:…
